Synthesis of(+)-solenopsin via Pd-catalyzed N-Alkylation and Cyclization
Synthesis of(+)-solenopsin via Pd-catalyzed N-Alkylation and Cyclization
复制标题
Pd催化N-烷基化和环化合成( )-solenopsin
DOI：
10.1093/bbb/zbaa014
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Suzuki;K.; Hattori;Y.; Kawamura;A.; Makabe;H.
Synthesis of (+)-solenopsin, a 2,6-disubstituted piperidine alkaloid, isolated from fire ants (Solenopsis), was achieved. Stereoselective construction oftrans-2,6-piperidine ring moiety was performed using palladium-catalyzed cyclization. Chain elongation using Grubbs 2nd catalyst followed by the reduction of double bond and the deprotection of the Cbz group afforded (+)-solenopsin.
