Tricks an IRES uses to enslave ribosomes.
Tricks an IRES uses to enslave ribosomes.
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DOI：
10.1016/j.tim.2012.08.002
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发表时间：
2012-11
影响因子：
15.9
通讯作者：
Thompson, Sunnie R.
中科院分区：
文献类型：
--
作者：
Thompson, Sunnie R.
In eukaryotes, mRNAs are primarily translated through a cap-dependent mechanism whereby initiation factors recruit the 40S ribosomal subunit to a cap structure at the 5’ end of the mRNA. However, some viral and cellular messages initiate protein synthesis without a cap. They use a structured RNA element termed an internal ribosome entry site (IRES) to recruit the 40S ribosomal subunit. IRESs were discovered over 20 years ago but only recently have studies using a model IRES from dicistroviruses expanded our understanding of how a three dimensional RNA structure can capture and manipulate the ribosome to initiate translation.
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