Technical note: 3D-printed MRI-compatible syringe pump.
Technical note: 3D-printed MRI-compatible syringe pump.
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技术说明：3D 打印的 MRI 兼容注射泵。
DOI：
10.1002/mp.16769
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发表时间：
2023
期刊：
影响因子：
3.8
通讯作者：
Kim,Harrison
中科院分区：
文献类型：
--
作者：
Holland,MartinD;Lee,Seth;Kim,Harrison
背景：在MRI过程中，动力注入器通常用于向受试者（例如，人类、动物、幽灵）输送造影剂，但它很昂贵，并且一次不能注射多个受试者。容纳多个注射器的传统注射泵通常与MRI不兼容，因此应放置在MRI室外。目的：开发一种具有成本效益，易于使用，可靠的注射泵的原型，该泵可以部署在临床MRI孔内并在扫描期间进行操作。方法采用Solidworks三维建模软件设计MRI兼容注射泵（MSP），并用Raise3D Pro2打印机制作。MSP被设计为同时注入多达三个注射器。喷射速度主要由擒纵单元的不同齿轮组控制，并通过插针改变游丝的有效长度来进一步调节。MSP用三组齿轮（齿轮比：0.20:1,0.56:1和1.09:1）和10个不同的有效游丝长度在每个齿轮比进行评估。在每个注射速度下操作MSP时记录视频，以计算5 mL注射器的体积注射速率（mL/s）。在每个注射速度下，MSP重复操作5次，计算体积注射速率的平均值和标准差。结果3种齿轮比（0.20:1、0.56:1和1.09:1）下游丝全长度时的体积注射速率分别为0.209±0.003 mL/s、0.411±0.002 mL/s和0.625±0.006 mL/s。10种不同有效游丝长度下，齿轮组1（齿轮比为0.20:1）的注射速率由0.273±0.001 mL/s降低至0.245±0.001 mL/s，减小幅度为0.003 mL/s （r= 0.997,p< 0.001）。齿轮组2（齿轮比为0.56:1）的注射速率从0.519±0.003 mL/s下降到0.469±0.003 mL/s，减少了0.006 mL/s (r= 0.987,p< 0.001)；齿轮组3（齿轮比为1.09:1）的注射速率从0.779±0.012 mL/s下降到0.709±0.005 mL/s，减少了0.007 mL/s （r= 0.963,p< 0.001）。注射速率测量的变异系数为0.727±0.346%。MSP是一种便携式设备，可以在扫描过程中可靠地向临床MRI孔内的多个受试者输送液体剂。
BackgroundA power injector is typically employed to deliver a contrast agent to a subject (e.g., humans, animals, phantoms) during MRI, but it is costly and cannot inject more than one subject at a time. Conventional syringe pumps housing multiple syringes are typically non‐MRI compatible and, thus, should be placed outside the MRI room.PurposeTo develop the prototype of a cost‐effective, easy‐to‐use, reliable syringe pump that could be deployed inside a clinical MRI bore and operated on during a scan.MethodsThe MRI‐compatible syringe pump (MSP) was designed using Solidworks 3D modeling software and fabricated using a Raise3D Pro2 Printer. The MSP was designed to infuse up to three syringes simultaneously. The injection speed was mainly controlled with different gear sets in the escapement unit and further adjusted by changing the effective hairspring length via a pinch pin. The MSP was evaluated with three gear sets (gear ratios: 0.20:1, 0.56:1, and 1.09:1) and 10 different effective hairspring lengths at each gear ratio. A video was recorded while operating MSP at each injection speed to calculate the volume injection rate of a 5‐mL syringe (mL/s). The MSP was operated five times repeatedly at each injection speed, and the mean and standard deviation of the volume injection rate were calculated.ResultsThe volume injection rates produced by three gear ratios (0.20:1, 0.56:1, and 1.09:1) were 0.209 ± 0.003 mL/s, 0.411 ± 0.002 mL/s, and 0.625 ± 0.006 mL/s, respectively, at the full hairspring length. The injection rates of gear set 1 (gear ratio: 0.20:1) decreased from 0.273 ± 0.001 mL/s to 0.245 ± 0.001 mL/s with a decrement of 0.003 mL/s for 10 different effective hairspring lengths (r= 0.997,p< 0.001). The injection rates of gear set 2 (gear ratio: 0.56:1) decreased from 0.519 ± 0.003 mL/s to 0.469 ± 0.003 mL/s with a decrement of 0.006 mL/s (r= 0.987,p< 0.001), and that of gear set 3 (gear ratio: 1.09:1) decreased from 0.779 ± 0.012 mL/s to 0.709 ± 0.005 mL/s with a decrement of 0.007 mL/s (r= 0.963,p< 0.001). The coefficient of variation in the injection rate measurement was 0.727 ± 0.346%.ConclusionsThe MSP is a portable device that can reliably deliver a liquid agent to multiple subjects inside a clinical MRI bore during a scan.