Effects of lactose on intestinal calcium absorption in normal and lactase-deficient subjects
Effects of lactose on intestinal calcium absorption in normal and lactase-deficient subjects
复制标题
乳糖对正常和乳糖酶缺乏受试者肠道钙吸收的影响
DOI：
10.1016/0016-5085(83)90194-4
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发表时间：
1983
期刊：
影响因子：
29.4
通讯作者：
D. Alfred
中科院分区：
文献类型：
--
作者：
B. Cochet;A. Jung;Marthe Griessen;P. Bartholdi;P. Schaller;D. Alfred
研究了12例乳糖酶正常和7例乳糖缺乏对肠道钙吸收的影响。通过使用双同位素技术比较每个受试者在口服或不口服50g乳糖的情况下的钙吸收情况。用反褶积法测定了动力学参数。在正常乳糖酶组中，乳糖以最大速率延长吸收时间，从而使总钙分数吸收从0.224±0.039增加到0.356±0.076 （p < 0.001）。乳糖酶缺乏组总吸收量由0.255±0.039降低至0.209±0.032 (p < 0.005)；这种影响导致了最大吸收率的降低。单独摄入钙时，两组间无显著差异。这些结果表明，乳糖对钙吸收的影响依赖于肠道乳糖酶活性。
The effect of lactose on intestinal calcium absorption was studied in 12 normal-lactase subjects and 7 lactose-deficient subjects. Calcium absorotion was compared by using the double isotope technique with or without the presence of an oral load of 50 g of lactose in each subject. The kinetic parameters were measured by the deconvolution method. In the normal lactase group, the lactose prolonged the duration of absorption at a maximum rate and therefore increased the total fractional calcium absorption from 0.224 ± 0.039 to 0.356 ± 0.076 (p < 0.001). In the lactase-deficient subjects, the lactose decreased the total absorption from 0.255 ± 0.039 to 0.209 ± 0.032 (p < 0.005); this effect resulted in a decrease of the maximum absorption rate. There was no significant difference between the two groups when calcium was ingested alone. These results indicate that the effect of lactose on calcium absorption is dependent on intestinal lactase activity.