Progesterone receptors mediate male aggression toward infants
Progesterone receptors mediate male aggression toward infants
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DOI：
10.1073/pnas.0130100100
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发表时间：
2003-02
影响因子：
11.1
通讯作者：
J. S. Schneider;M. Stone;K. Wynne-Edwards;T. Horton;J. Lydon;B. O’Malley;J. Levine
中科院分区：
文献类型：
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作者：
J. S. Schneider;M. Stone;K. Wynne-Edwards;T. Horton;J. Lydon;B. O’Malley;J. Levine
调节男性对婴儿攻击的神经内分泌机制尚不清楚。虽然已知睾酮在其他社会环境中增强攻击性，但它调节对婴儿的攻击性的证据尚不明确。我们发现雄性孕激素受体敲除（PRKO）小鼠没有杀婴行为，对幼鼠的攻击性很小。雄性PRKO小鼠也表现出显著增强的亲代行为。在野生型小鼠中，阻断PR诱导的行为表型与PRKO雄性小鼠相似，而黄体酮则加剧了对婴儿的攻击倾向。相比之下，针对成年男性的攻击行为不受孕激素、PR拮抗剂或PR基因缺失的影响。先前认为pr在雄性动物中的重要性降低，但在雄性小鼠中，pr在调节婴儿导向行为方面发挥着关键和特定的作用。
Neuroendocrine mechanisms that mediate male aggression toward infants are poorly understood. Although testosterone is known to enhance aggression in other social contexts, evidence that it modulates aggression toward infants is equivocal. We have found that male progesterone receptor knockout (PRKO) mice exhibit no infanticidal behavior and little aggression toward young. Male PRKO mice also display significantly enhanced parental behaviors. In wild-type mice, blockade of PR induces a behavioral phenotype similar to that of the PRKO males, whereas progesterone exacerbates aggressive tendencies toward infants. Aggressive behaviors directed toward adult males, by contrast, are unaffected by progesterone, PR antagonism, or PR gene deletion. Previously thought to be of diminished importance in male animals, PRs play a critical and specific role in modulating infant-directed behaviors in male mice.