Dysembryoplastic neuroepithelial tumor: an immunohistochemical study with myelin oligodendrocyte glycoprotein.
Dysembryoplastic neuroepithelial tumor: an immunohistochemical study with myelin oligodendrocyte glycoprotein.
复制标题
胚胎发育不良神经上皮肿瘤：髓磷脂少突胶质细胞糖蛋白的免疫组织化学研究。
DOI：
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发表时间：
2000
影响因子：
4.6
通讯作者：
Kondi Wong
中科院分区：
文献类型：
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作者：
K. Gyure;Glenn D. Sandberg;R. Prayson;Alan L. Morrison;Regina C. Armstrong;Kondi Wong
背景
胚胎发育不良神经上皮肿瘤（DNT）是一种罕见的病变，其特征是神经元、星形胶质细胞和少突胶质细胞（OLC）的异质群。 DNT 及其组成细胞（尤其是 OLC）的基本性质仍未解决；一些作者赞成神经元起源，而另一些作者则提出这些细胞的神经胶质或混合起源。
设计
我们检查了 11 个带有髓磷脂少突胶质细胞糖蛋白（成熟少突胶质细胞标记物）抗体的 DNT。
结果
所有研究的 DNT（7 名男性，4 名女性；患者年龄范围为 2-37 岁）均由不同比例的神经元、星形胶质细胞和 OLC 组成。在 11 例中有 9 例的许多 OLC 中发现了髓磷脂少突胶质细胞糖蛋白的膜或细胞质免疫反应性。髓鞘少突胶质细胞糖蛋白阳性 OLC 的数量存在差异：> 75% 的 OLC 阳性 5 例，25% 至 75% 的 OLC 阳性 2 例，<25% 的 OLC 阳性 2 例。
结论
这些发现表明，许多 OLC 代表成熟的少突胶质细胞，并支持 DNT 是由多种成熟细胞类型组成的异质性病变的观点。
CONTEXT
The dysembryoplastic neuroepithelial tumor (DNT) is an uncommon lesion characterized by a heterogeneous population of neurons, astrocytes, and oligodendroglia-like cells (OLCs). The basic nature of the DNT and its constituent cells, particularly the OLCs, remains unresolved; some authors favor a neuronal origin, and others propose a glial or mixed origin for these cells.
DESIGN
We examined 11 DNTs with antibodies to myelin oligodendrocyte glycoprotein, a marker of mature oligodendrocytes.
RESULTS
All DNTs studied (7 from males, 4 from females; age range of patients, 2-37 years) were composed of varying proportions of neurons, astrocytes, and OLCs. Membrane or cytoplasmic immunoreactivity for myelin oligodendrocyte glycoprotein was found in many OLCs in 9 of 11 cases. The number of myelin oligodendrocyte glycoprotein-positive OLCs was variable: >75% of the OLCs were positive in 5 cases, 25% to 75% of the OLCs were positive in 2 cases, and <25% of the OLCs were positive in 2 cases.
CONCLUSION
These findings suggest that many of the OLCs represent mature oligodendrocytes and support the notion that DNTs are heterogenous lesions composed of multiple, mature cell types.