Cross-correlations between three units in cat primary auditory cortex
Cross-correlations between three units in cat primary auditory cortex
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DOI：
10.1016/j.heares.2013.07.019
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发表时间：
2013-10-01
期刊：
影响因子：
2.8
通讯作者：
Shaw, Gregory
中科院分区：
文献类型：
--
作者：
Eggermont, Jos J.;Munguia, Raymundo;Shaw, Gregory
在这里，我们使用修改后的联合笔刺激时间直方图（JPSTH）研究猫听觉皮层神经元之间的三重相关性。修改后的过程允许将xy对相关性分解为由于x和y单元与触发单元的相关性而产生的部分，以及剩余的“对相关性”。我们分析了16组15分钟持续时间的静态自发记录在初级听觉皮层（AI）之间的11和14个电极从2个阵列的8个电极，每个提供自发放电率超过0.22 sp/s，并为可靠的频率调谐曲线，可以获得和特征频率（CF）估计。因此，我们评估了11，282个条件互相关函数。条件互相关的预测值等于单元xy之间的传统成对相关函数，该预测值是在假设触发单元对xy对相关性没有影响但使用相同分数的xy尖峰的基础上计算的。由于x和/或y单元与触发单元的相关性，xy对的条件相关性随着xy对到触发单元的几何平均距离而减小，但与对互相关系数无关。条件对相关系数估计为测量的对相关系数的78%。假设其他电极上的单元活动对条件相关性的几何递减效应，我们估计了大量贡献单元在该相关性的35-50处对测量的配对相关性的潜在贡献。这表明，常规测量的对相关性氯胺酮麻醉下的听觉皮层高估了“真正的对相关性”，可能导致大量的共同输入，潜在的高达2倍。(C)2013爱思唯尔有限公司版权所有。
Here we use a modification of the Joint-Pen-Stimulus-Time histogram (JPSTH) to investigate triple correlations between cat auditory cortex neurons. The modified procedure allowed the decomposition of the xy-pair correlation into a part that is due to the correlation of the x and y units with the trigger unit, and a remaining 'pair correlation'. We analyzed 16 sets of 15-minute duration stationary spontaneous recordings in primary auditory cortex (AI) with between 11 and 14 electrodes from 2 arrays of 8 electrodes each that provided spontaneous firing rates above 0.22 sp/s and for which reliable frequency-tuning curves could be obtained and the characteristic frequency (CF) was estimated. Thus we evaluated 11,282 conditional cross-correlation functions.The predictor for the conditional cross-correlation, calculated on the assumption that the trigger unit had no effect on the xy-pair correlation but using the same fraction of xy spikes, was equal to the conventional pair-wise correlation function between units xy. The conditional correlation of the xy-pair due to correlation of the x and/or y unit with the trigger unit decreased with the geometric mean distance of the xy pair to the trigger unit, but was independent of the pair cross-correlation coefficient. The conditional pair correlation coefficient was estimated at 78% of the measured pair correlation coefficient. Assuming a geometric decreasing effect of activities of units on other electrodes on the conditional correlation, we estimated the potential contribution of a large number of contributing units on the measured pair correlation at 35-50 of that correlation. This suggests that conventionally measured pair correlations in auditory cortex under ketamine anesthesia overestimate the 'true pair correlation', likely resulting from massive common input, by potentially up to a factor 2. (C) 2013 Elsevier B.V. All rights reserved.