Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats.
Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats.
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谷氨酸二甲酯对喂养麻醉大鼠的 GLP-1 促胰岛素作用的增强作用。
DOI：
10.3892/ijmm.8.5.531
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发表时间：
2001
影响因子：
5.4
通讯作者：
W. Malaisse
中科院分区：
文献类型：
--
作者：
J. Cancelas;M. Villanueva;I. Valverde;W. Malaisse
L-谷氨酸二甲酯（DMG）刺激胰岛素释放，并被认为是治疗非胰岛素依赖型糖尿病的可能促胰岛素工具。从这个角度出发，研究了DMG是否增强了进食麻醉大鼠中对GLP-1的B细胞分泌应答。DMG的初始恒定输注（1.0微摩尔，然后0.5微摩尔/分钟，均为每克体重）引起血浆胰岛素浓度的快速和持续增加，并增加GLP-1引起的胰岛素释放。因此，DMG确实是一种增强GLP-1促胰岛素作用的合适工具。
The dimethyl ester of L-glutamic acid (DMG) stimulates insulin release and was proposed as a possible insulinotropic tool in the treatment of non-insulin-dependent diabetes. In such a perspective, it was investigated whether DMG enhances the B-cell secretory response to GLP-1 in fed anaesthetized rats. The primed constant infusion of DMG (1.0 micromol and then 0.5 micromol/min, both per g body wt.) provoked a rapid and sustained increase in plasma insulin concentration and augmented the release of insulin caused by GLP-1. Thus, DMG indeed appears as a suitable tool to potentiate the insulinotropic action of GLP-1.