Place-related neural responses in the monkey hippocampal formation in a virtual space
Place-related neural responses in the monkey hippocampal formation in a virtual space
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DOI：
10.1002/hipo.20108
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发表时间：
2005-01-01
期刊：
影响因子：
3.5
通讯作者：
Nishijo, H
中科院分区：
文献类型：
--
作者：
Hori, E;Nishio, Y;Nishijo, H
啮齿动物海马结构（HF）的位置细胞被认为是空间认知地图的神经基质。位置细胞的这种特定空间特性受到两种另类线索（即，迷宫内局部和远端线索）以及独特感觉输入;由远端线索发出信号的上下文允许局部和独特线索用于迷宫内的空间调谐。为了研究远端线索对灵长类动物HF神经元位置相关活动的影响，记录了228个神经元从猴子HF在虚拟导航过程中在类似的情况下，啮齿动物水迷宫，其中远端线索是重要的，以确定动物的位置。72个神经元的子集在一个或多个虚拟空间中显示与位置相关的活动。大多数与地点有关的反应消失或改变了它们的空间调谐（即，重新映射）。猴HF的这些特征可能是人类情景记忆的神经生理学基础。(c)2005 Wiley-Liss，Inc.
Place cells in the rodent hippocampal formation (HF) are suggested to be the neural substrate for a spatial cognitive map. This specific spatial property of the place cells are regulated by both allothetic cues (i.e., intramaze local and distal cues) as well as idiothetic sensory inputs; the context signaled by the distal cues allows local and idiothetic cues to be employed for spatial tuning within the maze. To investigate the effects of distal cues on place-related activity of primate HF neurons, 228 neurons were recorded from the monkey HF during virtual navigation in a similar situation to a rodent water maze, in which distal cues were important to locate the animal's position. A subset of 72 neurons displayed place-related activity in one or more virtual spaces. Most place-related responses disappeared or changed their spatial tuning (i.e., remapping) when the arrangements of the distal cues were altered/moved in the virtual spaces. These specific features of the monkey HF might underlie neurophysiological bases of human episodic memory. (c) 2005 Wiley-Liss, Inc.