Cardiovascular adaptations to 10 days of cycle exercise.
Cardiovascular adaptations to 10 days of cycle exercise.
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心血管对 10 天循环运动的适应。
DOI：
10.1152/jappl.1997.83.6.1900
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Spina,RJ
中科院分区：
文献类型：
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作者：
Mier,CM;Turner,MJ;Ehsani,AA;Spina,RJ
Mier、Constance M.、Michael J. Turner、Ali A. Ehsani 和 Robert J. Spina。10 天循环运动的心血管适应。应用。 Physiol.83(6): 1900–1906, 1997.—我们假设 10 天的训练会增强峰值运动期间的心输出量 (CO) 和每搏输出量 (SV)，并增加对 β-肾上腺素能刺激的正性肌力反应。十名受试者 [年龄 26 ± 2 (SE) 岁] 在自行车测力计上训练了 10 天。在运动高峰期，训练增加了摄氧量、CO 和 SV (P< 0.001)。在注射阿托品（1.0 mg）之前（基线）和之后以及四级剂量的多巴酚丁胺期间，通过二维超声心动图评估静息时的左心室（LV）大小和功能。左心室舒张末期直径随着训练而增加（P<0.02），而左心室壁厚度则没有变化。通过将缩短分数 (FS) 与估计的收缩末期壁应力 (ES) 相关联来评估左心室收缩性能。训练增加了 FS-ES 关系的斜率（P<0.05），表明收缩功能增强。斜率的增加与 CO (r= -0.71,P< 0.05) 和 SV (r= -0.70,P< 0.05) 的增加相关。血容量的增加还与CO（r=0.80，P<0.01）和SV（r=0.85，P<0.004）的增加相关。这些数据表明，10 天的训练增强了对 β-肾上腺素能刺激的正性肌力反应，这与峰值运动期间 CO 和 SV 的增加有关。
Mier, Constance M., Michael J. Turner, Ali A. Ehsani, and Robert J. Spina.Cardiovascular adaptations to 10 days of cycle exercise.J. Appl. Physiol.83(6): 1900–1906, 1997.—We hypothesized that 10 days of training would enhance cardiac output (CO) and stroke volume (SV) during peak exercise and increase the inotropic response to β-adrenergic stimulation. Ten subjects [age 26 ± 2 (SE) yr] trained on a cycle ergometer for 10 days. At peak exercise, training increased O2uptake, CO, and SV (P< 0.001). Left ventricular (LV) size and function at rest were assessed with two-dimensional echocardiography before (baseline) and after atropine injection (1.0 mg) and during four graded doses of dobutamine. LV end-diastolic diameter increased with training (P< 0.02), whereas LV wall thickness was unchanged. LV contractile performance was assessed by relating fractional shortening (FS) to the estimated end-systolic wall stress (ςES). Training increased the slope of the FS-ςESrelationship (P< 0.05), indicating enhanced systolic function. The increase in slope correlated with increases in CO (r= −0.71,P< 0.05) and SV (r= −0.70,P< 0.05). The increase in blood volume also correlated with increases in CO (r= 0.80,P< 0.01) and SV (r= 0.85,P< 0.004). These data show that 10 days of training enhance the inotropic response to β-adrenergic stimulation, associated with increases in CO and SV during peak exercise.