The therapeutic applications of celery oil seed extract on the plasticizer di(2-ethylhexyl) phthalate toxicity
The therapeutic applications of celery oil seed extract on the plasticizer di(2-ethylhexyl) phthalate toxicity
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DOI：
10.1177/0748233713475515
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发表时间：
2015-04-01
影响因子：
1.9
通讯作者：
El-Shinnawy, Nashwa A.
中科院分区：
文献类型：
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作者：
El-Shinnawy, Nashwa A.
本研究探讨了500 mg/kg和1000 mg/kg两种剂量的邻苯二甲酸二（2-乙基己基）酯（DEHP）对大鼠某些致动脉粥样硬化、致肥胖、抗氧化和肝功能的影响，并研究了芹菜油籽提取物6周的可能治疗剂量。两种剂量的DEHP均导致过氧化物酶体增殖物激活受体α（PPAR）信使RNA过度表达，肝脏重量、相对肝脏重量、血清胆固醇（Chol）、甘油三酯、低密度脂蛋白Chol、肝脏总脂质显著增加，沿着血清天冬氨酸转氨酶、丙氨酸转氨酶、血清内皮素1和肝组织硫代巴比妥酸反应物质（TBARS）。此外，大鼠DEHP给药导致最终体重、血清总蛋白、白蛋白、肝脏总蛋白和血清总一氧化氮显著降低。我们的研究证实了小累积剂量（50 μ l/kg，持续6周）的芹菜油籽提取物与DEHP的口服组合在改善DEHP的毒理学效应方面的作用，其表现为降低PPAR的表达、脂质谱、恢复肝功能、血管氧化应激和抑制TBARS活性。
The present study investigated the impact of two doses, 500mg/kg and 1000mg/kg, of di(2-ethylhexyl) phthalate (DEHP) and studied the possible therapeutic dose of celery oil seed extract for 6weeks on some atheroscelerogenic, obesogenic, antioxidant and liver functions in rats. Both doses of DEHP caused over-expression of peroxisome proliferator-activated receptor alpha (PPAR) messenger RNA with significant increase in liver weights, relative liver weights, serum cholesterol (Chol), triglycerides, low-density lipoprotein Chol, liver total lipids, along with an increase in the activities of serum aspartate aminotransferase, alanine aminotransferase, serum endothelin 1 and liver tissue thiobarbituric acid reactive substances (TBARS). Additionally, DEHP administration to rats resulted in significant decrease in final body weights, serum total protein, albumin, liver total protein and serum total nitric oxide. Our study confirmed the role of oral combination of Apium graveolens (celery) oil seed extract at small cumulative doses (50 mu l/kg for 6weeks) with DEHP in ameliorating the toxicological effects of DEHP, which was revealed in reducing the expression of PPAR, lipid profile, with restoring liver functions, vascular oxidative stress and inhibition of TBARS activity.