A new type of silica-coated Gd2(CO3)3:Tb nanoparticle as a bifunctional agent for magnetic resonance imaging and fluorescent imaging
A new type of silica-coated Gd2(CO3)3:Tb nanoparticle as a bifunctional agent for magnetic resonance imaging and fluorescent imaging
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DOI：
10.1088/0957-4484/23/20/205103
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发表时间：
2012-05
期刊：
影响因子：
3.5
通讯作者：
Yanli Wu;Xian-zhu Xu;Qun Tang;Yongxiu Li
中科院分区：
文献类型：
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作者：
Yanli Wu;Xian-zhu Xu;Qun Tang;Yongxiu Li
我们报道了一种新型的结合联合收割机光学和磁共振生物成像的双模纳米探针。采用简单的反相微乳液法和包覆工艺制备了二氧化硅包覆的Gd 2（CO 3）3：Tb纳米粒子，其平均粒径为16 nm，可分散于水中。如纳米探针的体外细胞成像所示，纳米探针在短时间内成功地实现了对胃癌SGC 7901细胞以及NCI-H460肺癌细胞的递送。此外，在高剂量下，它没有表现出细胞毒性或对肾细胞生长的不利影响的证据，这使得纳米探针的光学生物成像模式可用。还证明了使用纳米探针进行磁共振成像的可能性，纳米探针显示出清晰的T1加权效应，并可能作为双峰T1阳性造影剂。因此，由掺杂有稀土离子的碳酸盐纳米探针形成的新纳米探针提供了光学和磁共振成像的双重模态。
We report a new type of dual modal nanoprobe to combine optical and magnetic resonance bioimaging. A simple reverse microemulsion method and coating process was introduced to synthesize silica-coated Gd2(CO3)3:Tb nanoparticles, and the particles, with an average diameter of 16 nm, can be dispersed in water. As in vitro cell imaging of the nanoprobe shows, the nanoprobe accomplishes delivery to gastric SGC7901 cancer cells successfully in a short time, as well as NCI-H460 lung cancer cells. Furthermore, it presents no evidence of cell toxicity or adverse affect on kidney cell growth under high dose, which makes the nanoprobe’s optical bioimaging modality available. The possibility of using the nanoprobe for magnetic resonance imaging is also demonstrated, and the nanoprobe displays a clear T1-weighted effect and could potentially serve as a bimodal T1-positive contrast agent. Therefore, the new nanoprobe formed from carbonate nanoprobe doped with rare earth ions provides the dual modality of optical and magnetic resonance imaging.