The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation
The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation
复制标题
心房颤动中 circRNA、microRNA 和 mRNA 的综合调控网络
DOI：
10.3389/fgene.2019.00526
复制
发表时间：
2019-06-13
影响因子：
3.7
通讯作者：
Liu, Ban
中科院分区：
文献类型：
--
作者：
Jiang, Shengyang;Guo, Changfa;Liu, Ban
心房颤动（AF）是最常见的不规则心律，影响约1-2%的普通人群。作为缺血性卒中的潜在因素，AF也可导致心力衰竭。房颤发病机制复杂，至今仍不清楚。作为一类新的非编码RNA（non-coding RNA，ncRNA），circular RNA（circular RNA，circRNA）在发育过程、细胞功能调节、心脏疾病的发病机制和病理反应中起着关键作用，为研究房颤的发病机制提供了新的视角。为探讨房颤中circRNA的调控机制，特别是circRNA、microRNA和mRNA之间的复杂相互作用，我们收集了3例房颤患者和3例健康对照的心脏组织，用circRNA微阵列分析了其circRNA的表达。对差异表达的circRNA进行鉴定，并分析其相互作用的microRNA和mRNAs的生物学功能。我们的研究结果提供了新的见解的circRNA在AF中的作用，并提出了circRNA，microRNA和mRNA之间的高度可能的相互作用机制。
Atrial fibrillation (AF) is the most common irregular heart rhythm which influence approximately 1-2% of the general population. As a potential factor for ischemic stroke, AF could also cause heart failure. The mechanisms behind AF pathogenesis is complex and remains elusive. As a new category of non-coding RNAs (ncRNAs), circular RNAs (circRNAs) have been known as the key of developmental processes, regulation of cell function, pathogenesis of heart diseases and pathological responses which could provide novel sight into the pathogenesis of AF. circRNAs function as modulators of microRNAs in cardiac disease. To investigate the regulatory mechanism of circRNA in AF, especially the complex interactions among circRNA, microRNA and mRNA, we collected the heart tissues from three AF patients and three healthy controls and profiled their circRNA expressions with circRNA Microarray. The differentially expressed circRNAs were identified and the biological functions of their interaction microRNAs and mRNAs were analyzed. Our results provided novel insights of the circRNA roles in AF and proposed highly possible interaction mechanisms among circRNAs, microRNAs, and mRNAs.