Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel.
Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel.
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以色列犹太族群帕金森病的临床特征。
DOI：
10.1007/s00702-008-0074-z
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Melamed,E
中科院分区：
文献类型：
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作者：
Djaldetti,R;Hassin-Baer,S;Farrer,MJ;Vilariño-Güell,C;Ross,OA;Kolianov,V;Yust-Katz,S;Treves,TA;Barhum,Y;Hulihan,M;Melamed,E
以色列的也门犹太人是犹太侨民中一个独特的民族群体。对阿什肯纳兹和也门以色列帕金森病 (PD) 患者的临床结果、病程和 LRRK26055G > A (G2019S) 突变的基因检测进行了比较。也门人的发病年龄明显更年轻（P < 0.001）。初始症状、环境危险因素或运动/非运动现象发生率的分布没有差异。也门组的病情更严重（P<0.001），病程更快（P=0.006）。在德系犹太人中，Lrrk2 取代的频率为 12.7%，而在也门人中未观察到。这些结果表明，以色列犹太族群之间 PD 的严重程度和进展存在差异，但临床症状没有差异。 Lrrk2 G2019S 在德系犹太人中的高频率以及在也门犹太人中的缺失表明德系犹太人中存在特定的祖先遗传模式。
Yemenite Jews in Israel are a distinctive ethnic division of the Jewish diaspora. Clinical findings, disease course and genetic tests for theLRRK26055G > A (G2019S) mutation were compared between Ashkenazi and Yemenite Israeli patients with Parkinson’s disease (PD). Age of onset was significantly younger in the Yemenites (P< 0.001). There were no differences in the distribution of initial symptoms, environmental risk factors or rate of motor/non-motor phenomena. The Yemenite group had a more severe disease (P< 0.001), and a more rapid disease course (P= 0.006). The frequency of Lrrk2 substitution was 12.7% in the Ashkenazi group and was not observed in the Yemenites. These results show that there are differences between Israeli Jewish ethnic groups in the severity and progression of PD, but not in clinical symptoms. The high frequency of Lrrk2 G2019S in the Ashkenazi and its absence in the Yemenite Jews suggests a specific ancestral pattern of inheritance in Ashkenazi Jews.