MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes
MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes
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DOI：
10.1021/ja056354d
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发表时间：
2006-02-22
影响因子：
15
通讯作者：
Ono, A
中科院分区：
文献类型：
--
作者：
Miyake, Y;Togashi, H;Ono, A
汞离子的特异性结合出乎意料地显著稳定了DNA双链体中天然存在的胸腺嘧啶-胸腺嘧啶碱基错配。根据这一发现，我们制备了在所需位点含有金属介导的碱基对的DNA双链体，以及仅由胸腺嘧啶−HgII−胸腺嘧啶对组成的新型双螺旋结构。
The very specific binding of the HgIIion unexpectedly and significantly stabilizes naturally occurring thymine−thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired sites, as well as novel double helical architectures consisting only of thymine−HgII−thymine pairs.