EFFECTS OF OPIATE ANTAGONISTS ON SPATIAL MEMORY IN YOUNG AND AGED RATS
EFFECTS OF OPIATE ANTAGONISTS ON SPATIAL MEMORY IN YOUNG AND AGED RATS
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DOI：
10.1016/s0163-1047(85)90688-0
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
KING, R
中科院分区：
文献类型：
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作者：
GALLAGHER, M;BOSTOCK, E;KING, R
在年轻和老年雄性Long Evans大鼠中评估训练后给予阿片拮抗剂对空间记忆的影响。在实验I中，大鼠接受训练，访问每个八臂径向迷宫一次在一个会话，以获得食物奖励放置在每个arms. During训练结束时，老年大鼠需要显着更多的试验，以达到标准的性能相比，年轻的成熟大鼠。然而，在每次训练试验后立即给予阿片拮抗剂纳洛酮（2.0 mg/kg）并没有显著改变任何年龄组的准确表现率。在实验II中，年轻和老年大鼠，以前训练的一个类似的标准，在径向迷宫进行了测试，在相同的迷宫装置在新的空间环境。当动物暴露于新的空间信息时，使用受试者内平衡设计检查试验后阿片拮抗剂的作用。在实验IIa纳洛酮（2毫克/公斤）提高了年轻和老年大鼠的性能。在实验IIB中，发现纳洛酮（1.0 mg/kg）对提高两个年龄组的表现具有相当的效果。此外，在实验IIb中，在新的空间环境中测试的大鼠中发现了与年龄相关的显著缺陷。这些结果表明，阿片受体拮抗剂能够改善记忆的新的空间信息在年轻和老年大鼠的任务是敏感的行为缺陷在正常老化。
The effects of post-training opiate antagonist administration on spatial memory were assessed in young and aged male Long Evans rats. In Experiment I rats were trained to visit each arm of an eight-arm radial maze once in a session to obtain a food reward placed at the end of each arm. During training aged rats required significantly more trials to achieve criterion performance when compared to young mature rats. However, administration of the opiate antagonist naloxone (2.0 mg/kg) immediately after each training trial did not significantly alter the rate of achieving accurate performance in either age group. In Experiment II young and aged rats that were previously trained to a comparable criterion on the radial maze were tested on the same maze apparatus in novel spatial environments. When animals were exposed to novel spatial information, the effects of post-trial opiate antagonists were examined using a within-subjects counterbalanced design. In Experiment IIa naloxone (2 mg/kg) enhanced the performance of both young and aged rats. In Experiment IIB naltrexone (1.0 mg/kg) was found to have a comparable effect of enhancing the performance of both age groups. In addition, in Experiments IIb a significant age-related deficit was found in rats tested in novel spatial environments. These results indicate that opiate antagonists are capable of improving memory for new spatial information in both young and aged rats on a task that is sensitive to behavioral deficits during normal aging.