Autophagy favors Brucella melitensis survival in infected macrophages.
Autophagy favors Brucella melitensis survival in infected macrophages.
复制标题
自噬有利于布鲁氏菌在受感染的巨噬细胞中存活
DOI：
10.2478/s11658-012-0009-4
复制
发表时间：
2012-06
影响因子：
8.3
通讯作者：
Du G
中科院分区：
文献类型：
--
作者：
Guo F;Zhang H;Chen C;Hu S;Wang Y;Qiao J;Ren Y;Zhang K;Wang Y;Du G
本研究探讨了自噬在侵袭性细菌羊种布氏杆菌菌株16 M在小鼠巨噬细胞中的存活中的作用。在这里，发现羊种布鲁氏菌16 M触发自噬体形成，增强自噬通量并增加自噬标志物蛋白LC 3-II的表达水平。当3-甲基腺嘌呤（3-MA）抑制自噬时，布鲁氏菌的复制效率显著降低（p < 0.05）。这些结果表明，自噬有利于羊种布鲁氏菌16 M在鼠巨噬细胞中的存活。
This study investigated the role of autophagy in the survival of the invasive bacterium Brucella melitensis strain 16M in murine macrophages. Here, Brucella melitensis 16M was found to trigger autophagosome formation, enhance autophagy flux and increase the expression level of the autophagy marker protein LC3-II. When autophagy was pharmacologically inhibited by 3-methyladenine (3-MA), Brucella replication efficiency was significantly decreased (p < 0.05). These results suggest that autophagy favors Brucella melitensis 16M survival in murine macrophages.