Adrenoreceptor effects on rat muscle blood flow during treadmill exercise.
Adrenoreceptor effects on rat muscle blood flow during treadmill exercise.
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跑步机运动期间肾上腺素受体对大鼠肌肉血流量的影响。
DOI：
10.1152/jappl.1987.62.4.1465
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Armstrong,RB
中科院分区：
文献类型：
--
作者：
Laughlin,MH;Armstrong,RB
本研究的目的是研究肾上腺素能受体对大鼠骨骼肌内和骨骼肌间血流分布的影响。血流量测定与放射性标记的微球技术运动前和跑步机运动期间在15或60米/分。α-（酚妥拉明）或β-（普萘洛尔）肾上腺素能阻断药物的管理，然后血流量测定和结果与盐水治疗的大鼠。在运动前，α-阻滞导致总肌肉血流量和所有快收缩肌肉的增加，而由大于20%的慢收缩纤维组成的肌肉则没有效果。在以15米/分钟的速度运动期间，总肌肉血流量的正常增加被α-阻滞减弱。与对照组相比，伸肌高氧化（快和慢）肌纤维区的血流量减少，而伸肌白色区的血流量增加。β-阻滞剂倾向于在运动前和以15 m/min运动期间减少肌肉血流量，阻滞剂对血流量的影响与肌纤维类型之间没有明显的关系。这些影响的β-阻断运动过程中在60米/分钟不明显。我们得出结论，运动前α-受体的影响仅限于快速肌肉，而β-受体的影响是独立的纤维类型，β-受体有助于初始充血的运动在15米/分钟，β-受体的影响是负相关的代谢率。
The purpose of this study was to examine the effects of the adrenergic receptors on the distribution of blood flow within and among skeletal muscles in rats. Blood flow was measured with the radiolabeled microsphere technique before exercise and during treadmill exercise at 15 or 60 m/min. Alpha- (phentolamine) or beta- (propranolol) adrenergic blocking drugs were administered, and then blood flow was measured and results compared with those from saline-treated rats. Before exercise, alpha-blockade caused increases in total muscle blood flow and in all fast-twitch muscles, whereas muscles composed of greater than 20% slow-twitch fibers showed no effect. During exercise at 15 m/min, the normal increase in total muscle blood flow was attenuated by alpha-blockade. Compared with controls, blood flow was less in the high-oxidative (fast and slow) muscle fiber areas of extensor muscles, whereas blood flow to white areas of extensor muscles was increased. beta-Blockade tended to decrease muscle blood flow before exercise and during exercise at 15 m/min with no apparent relationship between the effects of blockade on blood flow and muscle fiber type. These effects of beta-blockade were not apparent during exercise at 60 m/min. We conclude that before exercise alpha-receptor effects are limited to fast muscle, whereas beta-receptor influences are independent of fiber type, beta-receptors contribute to the initial hyperemia of exercise at 15 m/min, and beta-receptor influence is inversely related to metabolic rate.