Transcatheter intraarterial perfusion: MR monitoring of chemoembolization for hepatocellular carcinoma-feasibility of initial clinical translation
Transcatheter intraarterial perfusion: MR monitoring of chemoembolization for hepatocellular carcinoma-feasibility of initial clinical translation
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DOI：
10.1148/radiol.2463070725
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发表时间：
2008-03-01
期刊：
影响因子：
19.7
通讯作者：
Omary, Reed A.
中科院分区：
文献类型：
--
作者：
Larson, Andrew C.;Wang, Dingxin;Omary, Reed A.
目的：前瞻性地验证术中经导管动脉灌注（TRIP）磁共振（MR）成像可以成功测量靶向肝细胞癌（HCC）及其邻近区域灌注减少的假设。介入放射学（IR）监测的经导管动脉化疗栓塞（TACE）期间周围肝组织。材料和方法：本前瞻性研究符合hippa标准，经机构审查委员会批准。使用MR-IR单元对10例HCC患者进行TACE（7例男性，3例女性，8例年龄小于69岁，2例年龄大于69岁）。应用TRIP磁共振成像监测TACE前后术中肿瘤灌注减少情况。导出时间-信号强度曲线，生成rtace前后肿瘤灌注时间-信号强度曲线下的半定量空间分辨区域图。采用混合模型分析比较肝肿瘤及邻近肝组织TACE前后的平均灌注值，alpha = 05。结果：在13个疗程的治疗过程中，18个单独的肿瘤用TRIP MR成像成功地测量了灌注减少。灌注图显示肿瘤灌注明显减少(P
Purpose: To prospectively test the hypothesis that intraprocedural transcatheter intraarterial perfusion (TRIP) magnetic resonance (MR) imaging can be used to successfully measure reductions in perfusion to the targeted hepatocellular carcinoma (HCC) and the adjacent. surrounding liver tissue during NAR-interventional radiology (IR)-monitored transcatheter arterial chemoembolization (TACE).Materials and methods: This HIPPA-compliant prospective study was approved by the institutional review board. An MR-IR unit was used to Perform TACE in 10 patients with HCC (seven male, three female; eight younger than 69 years, two older, than 69 years). Intraprocedural reductions in tumor perfusion before and after TACE were monitored with TRIP MR imaging. Time-signal intensity curves were derived, and semi-quantitative spatially resolved area under the time-signal intensity curve maps of tumor perfusion before and after r TACE were produced. Mean perfusion values before and after TACE for liver tumors and adjacent liver tissue were compared by using a mixed-model analysis, with alpha = 05.Results: Perfusion reductions were measured successfully with TRIP MR imaging in 18 separate tumors during 13 treatment sessions. Perfusion maps showed significant perfusion reductions for tumors (P