Monkeypox Outbreak — Nine States, May 2022
Monkeypox Outbreak — Nine States, May 2022
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DOI：
10.1111/ajt.16669
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发表时间：
2022-06
期刊：
影响因子：
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通讯作者：
F. Minhaj;Y. Ogale;F. Whitehill;Jordan M. Schultz;M. Foote;W. Davidson;C. Hughes;Kimberly Wilkins;L. Bachmann;R. Chatelain;Marisa A P Donnelly;Rafael M. Mendoza;Barbara L Downes;Mellisa Roskosky;M. Barnes;G. Gallagher;N. Basgoz;Victoria Ruiz;N. Kyaw;Amanda L Feldpausch;A. Valderrama;F. Alvarado-Ramy;C. Dowell;C. Chow;Yu Li;Laura A S Quilter;J. Brooks;D. Daskalakis;R. P. McClung;B. Petersen;I. Damon;C. Hutson;J. McQuiston;A. Rao;E. Belay;A. McCollum;Kristina M. Angelo;Matt Arduino;R. Arthur;N. Baird;Jonathan T. Batross;Amy Beeson;Jui A. Bhingarde;Michael Bowen;Clive M. Brown;C. Brown;Alexis W. Burakoff;K. Charniga;Tai-Ho Chen;S. Chen;P. Clay;James Cope;Jenny L. Cope;Michelle Addo Dankwa;L. Delaney;M. D. Perio;Michelle Decenteceo;K. Delea;Jeffrey B Doty;J. Duchin;Joseph Dunlap;Ryan Fagan;B. Furness;S. Gearhart;C. Gigante;Aubrey E. Gilliland;L. Gosdin;I. Griffin;Amanda Groccia;S. Guagliardo;Yonette Hercules;Kelly Jackson;Paulino Jarquin;R. Kachur;Alexander J. Kallen;Raymond Kao;A. Kelly;Mohammed Khan;T. Khān;Aaron D. Kofman;Krista Kornylo;D. Kuhar;Michael LaFlam;R. Lash;Andrew Lashombe;D. Lowe;A. MacGurn;Nina B. Masters;K. McCaffrey;Jenna L. Mink;B. Monroe;Clint N. Morgan;Y. Nakazawa;Julie Nash;Terese Navarra;Donovan Newton;Modupe O. V. Osinubi;Valentina Osorio;Christine Pearson;Julia K Petras;David H. Philpott;Amy Pickrel;Brandon Potvin;Lalita Priyamvada;Araceli Rey;Erin K. Ricketts;Sergio Rodríguez;J. Rushmore;P. S. Satheshkumar;H. Segaloff;Ahlia Sekkarie;Artee Sharma;Emily. Sims;Dallas Smith;T. Smith;Todd Smith;D. Solanky;Ian Spiknall;D. Stanek;M. Stenger;F. Strona;K. Tardivel;Eishita Tyagi;P. Wortley;D. Valencia;M. Waltenburg;E. Whitehouse;Marcia Wong
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作者：
F. Minhaj;Y. Ogale;F. Whitehill;Jordan M. Schultz;M. Foote;W. Davidson;C. Hughes;Kimberly Wilkins;L. Bachmann;R. Chatelain;Marisa A P Donnelly;Rafael M. Mendoza;Barbara L Downes;Mellisa Roskosky;M. Barnes;G. Gallagher;N. Basgoz;Victoria Ruiz;N. Kyaw;Amanda L Feldpausch;A. Valderrama;F. Alvarado-Ramy;C. Dowell;C. Chow;Yu Li;Laura A S Quilter;J. Brooks;D. Daskalakis;R. P. McClung;B. Petersen;I. Damon;C. Hutson;J. McQuiston;A. Rao;E. Belay;A. McCollum;Kristina M. Angelo;Matt Arduino;R. Arthur;N. Baird;Jonathan T. Batross;Amy Beeson;Jui A. Bhingarde;Michael Bowen;Clive M. Brown;C. Brown;Alexis W. Burakoff;K. Charniga;Tai-Ho Chen;S. Chen;P. Clay;James Cope;Jenny L. Cope;Michelle Addo Dankwa;L. Delaney;M. D. Perio;Michelle Decenteceo;K. Delea;Jeffrey B Doty;J. Duchin;Joseph Dunlap;Ryan Fagan;B. Furness;S. Gearhart;C. Gigante;Aubrey E. Gilliland;L. Gosdin;I. Griffin;Amanda Groccia;S. Guagliardo;Yonette Hercules;Kelly Jackson;Paulino Jarquin;R. Kachur;Alexander J. Kallen;Raymond Kao;A. Kelly;Mohammed Khan;T. Khān;Aaron D. Kofman;Krista Kornylo;D. Kuhar;Michael LaFlam;R. Lash;Andrew Lashombe;D. Lowe;A. MacGurn;Nina B. Masters;K. McCaffrey;Jenna L. Mink;B. Monroe;Clint N. Morgan;Y. Nakazawa;Julie Nash;Terese Navarra;Donovan Newton;Modupe O. V. Osinubi;Valentina Osorio;Christine Pearson;Julia K Petras;David H. Philpott;Amy Pickrel;Brandon Potvin;Lalita Priyamvada;Araceli Rey;Erin K. Ricketts;Sergio Rodríguez;J. Rushmore;P. S. Satheshkumar;H. Segaloff;Ahlia Sekkarie;Artee Sharma;Emily. Sims;Dallas Smith;T. Smith;Todd Smith;D. Solanky;Ian Spiknall;D. Stanek;M. Stenger;F. Strona;K. Tardivel;Eishita Tyagi;P. Wortley;D. Valencia;M. Waltenburg;E. Whitehouse;Marcia Wong
2022年5月17日，马萨诸塞州公共卫生部（MDPH）实验室响应网络（LRN）实验室通过实时聚合酶链反应（PCR）确认从马萨诸塞州居民获得的病变拭子中存在正痘病毒DNA。正痘病毒包括猴痘病毒，猴痘的病原体。随后于5月18日在CDC进行的实时PCR检测证实患者感染了西非猴痘病毒分支。此后，9个州报告了确诊病例。此外，28个国家和地区报告了实验室确诊病例，其中没有一个国家和地区有猴痘流行。5月17日，疾病预防控制中心与州和地方司法机构协调，启动了紧急响应，以确定，监测和调查美国的其他猴痘病例。这一应对措施包括发布健康警报网络健康咨询，制定临时公共卫生和临床建议，发布LRN检测指南，接待临床医生和公共卫生合作伙伴的外联电话，向公众传播健康传播信息，制定使用和发布医疗对策的协议，以及促进美国政府为准备和应对目的而储备的疫苗后预防（PEP）和抗病毒药物的交付。5月19日，建立了一个呼叫中心，为各州评估可能的猴痘病例提供指导，包括临床诊断和正痘病毒检测的建议。呼叫中心还收集有关可能案件的信息，以确定司法管辖区之间的联系。截至5月31日，这项调查在美国确定了17例病例;大多数病例（16例）被诊断为同性恋、双性恋或男男性行为者（MSM）。正在进行的调查表明，人际社区传播，CDC敦促卫生部门，临床医生和公众保持警惕，制定适当的感染预防和控制措施，并向公共卫生当局通报疑似病例，以减少疾病传播。公共卫生当局正在确定病例并进行调查，以确定可能的来源并防止进一步传播。这项活动由CDC审查，并根据适用的联邦法律和CDC政策进行。
On May 17, 2022, the Massachusetts Department of Public Health (MDPH) Laboratory Response Network (LRN) laboratory confirmed the presence of orthopoxvirus DNA via real-time polymerase chain reaction (PCR) from lesion swabs obtained from a Massachusetts resident. Orthopoxviruses include Monkeypox virus, the causative agent of monkeypox. Subsequent real-time PCR testing at CDC on May 18 confirmed that the patient was infected with the West African clade of Monkeypox virus. Since then, confirmed cases* have been reported by nine states. In addition, 28 countries and territories,† none of which has endemic monkeypox, have reported laboratory-confirmed cases. On May 17, CDC, in coordination with state and local jurisdictions, initiated an emergency response to identify, monitor, and investigate additional monkeypox cases in the United States. This response has included releasing a Health Alert Network (HAN) Health Advisory, developing interim public health and clinical recommendations, releasing guidance for LRN testing, hosting clinician and public health partner outreach calls, disseminating health communication messages to the public, developing protocols for use and release of medical countermeasures, and facilitating delivery of vaccine postexposure prophylaxis (PEP) and antivirals that have been stockpiled by the U.S. government for preparedness and response purposes. On May 19, a call center was established to provide guidance to states for the evaluation of possible cases of monkeypox, including recommendations for clinical diagnosis and orthopoxvirus testing. The call center also gathers information about possible cases to identify interjurisdictional linkages. As of May 31, this investigation has identified 17§ cases in the United States; most cases (16) were diagnosed in persons who identify as gay, bisexual, or men who have sex with men (MSM). Ongoing investigation suggests person-to-person community transmission, and CDC urges health departments, clinicians, and the public to remain vigilant, institute appropriate infection prevention and control measures, and notify public health authorities of suspected cases to reduce disease spread. Public health authorities are identifying cases and conducting investigations to determine possible sources and prevent further spread. This activity was reviewed by CDC and conducted consistent with applicable federal law and CDC policy.¶.