Effects of glycinergic inhibition failure on respiratory rhythm and pattern generation.
Effects of glycinergic inhibition failure on respiratory rhythm and pattern generation.
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DOI：
10.1016/b978-0-444-63274-6.00002-3
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发表时间：
2014
影响因子：
--
通讯作者：
Rybak, Ilya A.
中科院分区：
文献类型：
--
作者：
Shevtsova, Natalia A.;Buesselberg, Dietrich;Molkov, Yaroslav I.;Bischoff, Anne M.;Smith, Jeffrey C.;Richter, Diethelm W.;Rybak, Ilya A.
关键词：
呼吸网络神经元之间的抑制性相互作用参与节律的产生和模式的形成。利用脑干呼吸网络的计算模型，我们研究了抑制甘氨酸能抑制对不同类型呼吸神经元活动的可能影响。我们的研究表明，对甘氨酸能抑制的渐进性抑制影响到该网络的所有神经元，并扰乱了参与吸气终止的神经回路。原因是以吸气神经元为靶点的吸气后抑制功能障碍，这往往导致这些神经元的不规则提前重新激活，产生两次或多次短时吸气爆发。甘氨酸能抑制作用的增强阻断导致了窒息的吸气活动。在低氧期间，甘氨酸能抑制的类似干扰也会发生。然而，长时间低氧的一个明显区别是，节律终止于呼气性呼吸暂停。讨论了甘氨酸能抑制对正常呼吸节律产生的关键作用以及其减少的后果，包括在病理条件下。
Inhibitory interactions between neurons of the respiratory network are involved in rhythm generation and pattern formation. Using a computational model of brainstem respiratory networks, we investigated the possible effects of suppressing glycinergic inhibition on the activity of different respiratory neuron types. Our study revealed that progressive suppression of glycinergic inhibition affected all neurons of the network and disturbed neural circuits involved in termination of inspiration. Causal was a dysfunction of postinspiratory inhibition targeting inspiratory neurons, which often led to irregular preterm reactivation of these neurons, producing double or multiple short-duration inspiratory bursts. An increasing blockade of glycinergic inhibition led to apneustic inspiratory activity. Similar disturbances of glycinergic inhibition also occur during hypoxia. A clear difference in prolonged hypoxia, however, is that the rhythm terminates in expiratory apnea. The critical function of glycinergic inhibition for normal respiratory rhythm generation and the consequences of its reduction, including in pathological conditions, are discussed.