Triterpene Saponins from Clematis chinensis and Their Potential Anti-inflammatory Activity
Triterpene Saponins from Clematis chinensis and Their Potential Anti-inflammatory Activity
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DOI：
10.1021/np100057y
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发表时间：
2010-07-01
影响因子：
5.1
通讯作者：
Tu, Pengfei
中科院分区：
文献类型：
--
作者：
Fu, Qiang;Zan, Ke;Tu, Pengfei
从铁线莲根和根茎中分离得到7个新的三萜皂苷：铁线莲皂苷A-G(1-7)和17个已知的皂苷(8-24)。根据波谱证据和水解物确定了它们的结构。化合物1、3-7和20-24对COX-1和COX-2酶有抑制活性。
Seven new triterpene saponins, clematochinenosides A-G (1-7), together with 17 known saponins (8-24), were isolated from the roots and rhizomes of Clematis chinensis. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. Compounds 1, 3-7, and 20-24 showed inhibitory activities against COX-1 and COX-2 enzymes.