Altered hippocampal-prefrontal activation in HIV patients during episodic memory encoding
Altered hippocampal-prefrontal activation in HIV patients during episodic memory encoding
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DOI：
10.1212/01.wnl.0000218305.09183.70
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发表时间：
2006-06-13
期刊：
影响因子：
9.9
通讯作者：
Stern, C. E.
中科院分区：
文献类型：
--
作者：
Castelo, J. M. B.;Sherman, S. J.;Stern, C. E.
目的：探讨HIV感染者在情景编码过程中大脑皮层-前额叶回路的完整性。研究方法：使用功能性MRI观察14名HIV阳性受试者和14名年龄和教育程度匹配的对照受试者在执行情景编码任务时血氧水平依赖（BOLD）信号的变化。受试者还完成了注意力和记忆力的神经心理学测量。结果：行为结果显示，在神经心理性能没有显着差异。功能磁共振成像结果显示，虽然两组都招募了已知对成功编码很重要的大脑区域，包括双侧内侧颞叶和下前额叶回，但HIV组在右后海马、右额下回和左舌回的信号强度变化显著降低。此外，HIV组在侧额和后顶叶区域表现出更多的活动。结论：这项研究表明，在HIV阳性患者的情景编码过程中，前额叶-前额叶区域的完整性发生了改变。这些结果扩展了以前的研究，这些研究记录了HIV对额纹状体回路的影响，并表明病毒在功能上也影响海马系统。
Objective: To investigate the integrity of hippocampal-prefrontal circuitry during episodic encoding in patients with HIV. Methods: Functional MRI was used to observe changes in blood oxygenation level-dependent ( BOLD) signal in 14 HIV-positive participants and 14 age- and education-matched control subjects while performing an episodic encoding task. Subjects also completed neuropsychological measures of attention and memory. Results: Behavioral results revealed no significant differences in neuropsychological performance. The fMRI results revealed that while both groups recruited brain regions known to be important for successful encoding, including bilateral medial temporal lobes and inferior prefrontal gyri, the HIV group demonstrated significantly reduced signal intensity changes in the right posterior hippocampus, right inferior frontal gyrus, and left lingual gyrus. Additionally, the HIV group exhibited more activity within lateral frontal and posterior parietal regions. Conclusions: This study demonstrates altered integrity of hippocampal-prefrontal regions during episodic encoding in HIV-positive patients. These results extend previous studies that have documented the effects of HIV on fronto-striatal circuits, and suggest the virus functionally impacts the hippocampal system as well.