Seizure disorders, depression, and health-related quality of life
Seizure disorders, depression, and health-related quality of life
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DOI：
10.1016/j.yebeh.2003.10.015
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发表时间：
2004-02-01
影响因子：
2.6
通讯作者：
Szaflarski, M
中科院分区：
文献类型：
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作者：
Szaflarski, JP;Szaflarski, M
疾病和情绪状态是生活质量（QOL）的重要决定因素。由于情绪状态，生活质量低，尤其是在精神疾病如抑郁症中。然而，由于身体发作、精神共病和心理社会因素（例如，耻辱）。在这项研究中，我们比较了癫痫发作性疾病和临床抑郁症的生活质量。根据我们早期的研究结果，我们假设癫痫患者的表现优于心因性非癫痫性发作（PNES）患者，我们推测PNES患者的生活质量相对于临床抑郁症也较低。我们使用多元回归估计癫痫发作类型（癫痫vs PNES）、抑郁和生活质量（SF-36）之间的关系，并使用单样本t检验将癫痫和PNES患者（n = 194）的SF-36评分与临床抑郁的标准数据进行比较。我们的研究结果表明，抑郁有助于穷人的生活质量在癫痫和PNES，但PNES患者，即使是那些没有抑郁症，有更差的生活质量与癫痫患者和抑郁症的正常人相比。我们的结论是，评估和治疗情绪状态是一样重要的治疗PNES本身时，照顾患者的PNES，这可能是改善他们的生活质量的第一步。(C)2003年爱思唯尔公司All rights reserved.
Disease and mood states are important determinants of quality of life (QOL). Low QOL, due to mood states, can be expected especially in psychiatric disorders such as depression. However, patients with seizure disorders may be even more affected because of the combined burden of physical episodes, psychiatric comorbidities, and psychosocial factors (e.g., stigma). In this study, we compare the quality of life in seizure disorders and clinical depression. Based on our earlier findings, we hypothesize that epilepsy patients fare better than patients with psychogenic, nonepileptic seizures (PNES), and we speculate that QOL in PNES is also lower relative to clinical depression. We estimate the relationships between type of seizures (epilepsy vs PNES), depression, and QOL (SF-36) using multiple regression, and we compare the SF-36 scores of patients with epilepsy and PNES (n = 194) with the normative data for clinical depression using one-sample t tests. Our findings indicate that depression contributes to the poor QOL in both epilepsy and PNES, but the patients with PNES, even those without depression, have worse QOL compared with both the epilepsy patients and the depression norms. We conclude that evaluating and treating mood states is as important as treating PNES itself when caring for patients with PNES, and it might be the first step toward improving their QOL. (C) 2003 Elsevier Inc. All rights reserved.