Low expression of WW domain-containing oxidoreductase associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection.
Low expression of WW domain-containing oxidoreductase associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection.
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含WW结构域的氧化还原酶的低表达与肝细胞癌的侵袭性和治愈性切除后的复发相关
DOI：
10.1002/cam4.1591
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发表时间：
2018-07
期刊：
影响因子：
4
通讯作者：
Ren N
中科院分区：
文献类型：
--
作者：
Zhou C;Chen W;Sun J;Atyah M;Yin Y;Zhang W;Guo L;Ye Q;Dong Q;Shi Y;Ren N
含有WW结构域的氧化还原酶（WWOX）具有蛋白质相互作用结构域，被认为是肿瘤抑制因子，已知在抗血管生成和癌症进展中发挥重要作用。本研究旨在探讨肝细胞癌（HCC）患者肝切除术后WWOX表达的预后价值。此外，我们打算制定一个有价值的肝癌预后诺模图。本研究纳入了2009年1月至2010年1月期间接受肝切除术的182例HCC患者。然后使用组织微阵列上的qRT-PCR、Western印迹和免疫组织化学来确定WWOX的表达水平。建立了WWOX表达水平在患者预后和结果中的作用的评估。与邻近无肿瘤组织相比，发现WWOX表达降低，导致总生存期（OS）和无复发生存期（RFS）变差，因此被认为是HCC预后的独立负性因素。构建了两个列线图，包括WWOX、甲胎蛋白（AFP）、肿瘤大小和γ-谷氨酰转移酶（γ-GT），以获得在C指数和OS和RFS决策曲线分析（DCA）的临床净获益方面优于传统分期系统的上级区分能力。我们的数据表明，WWOX表达与HCC切除后的侵袭性和复发密切相关。通过将WWOX纳入列线图中的其他先进和准确的预测模型可以帮助预测HCC患者的OS或RFS。
WW domain‐containing oxidoreductase (WWOX), which has a protein‐interaction domain and is regarded to be a tumor suppressor, has been known to play an important role in anti‐angiogenesis and cancer progression. This study aimed to investigate prognostic values of WWOX expression in hepatocellular carcinoma (HCC) patients after hepatectomy. Additionally, we intended to formulate a valuable prognostic nomogram for HCCs. 182 HCC patients who underwent hepatectomy from January 2009 to January 2010 were enrolled in our study. qRT‐PCR, Western blot, and immunohistochemistry on tissue microarrays were then used to determine the expression levels of WWOX. An evaluation of the role of WWOX expression levels in the prognosis and outcome of patients was established. A decrease in the expression of WWOX was found when compared to adjacent tumor‐free tissues, which led to worse overall survival (OS) and recurrence‐free survival (RFS) and, therefore, was considered as an independent negative factor in the prognosis of HCC. Two nomograms, comprising WWOX, alpha‐fetoprotein (AFP), tumor size, and γ‐glutamyltransferase (γ‐GT), were constructed to obtain superior discriminatory abilities than conventional staging systems in terms of C‐index and clinical net benefit on decision curve analysis (DCA) for OS and RFS. Our data suggest that WWOX expression is strongly related to HCC post‐resection aggressiveness and recurrence. Additional advanced and accurate predictive model through the incorporation of WWOX into nomogram could help predict OS or RFS for HCC patients.
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作者：
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DOI：
10.1016/s1470-2045(14)71116-7
发表时间：
2015-04
期刊：
The Lancet. Oncology
影响因子：
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作者：
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通讯作者：
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