The effect of simvastatin on systemic inflammation and endothelial dysfunction induced by periodontitis
The effect of simvastatin on systemic inflammation and endothelial dysfunction induced by periodontitis
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DOI：
10.1111/jre.12145
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发表时间：
2014-10-01
影响因子：
3.5
通讯作者：
Fernandes, D.
中科院分区：
文献类型：
--
作者：
Machado, W. M.;Prestes, A. P.;Fernandes, D.
背景与目的：研究表明，牙周炎可引起全身炎症，损害内皮功能，增加心血管风险。本研究的目的是评估辛伐他汀对牙周炎引起的全身炎症标志物和内皮功能障碍的影响。材料与方法：采用Wistar大鼠结扎诱导实验性牙周炎。术后8天，结扎组和假手术组随机分为辛伐他汀组和载药组，每天1次，直到第14天，评估乙酰胆碱和硝普钠对血压的影响。采集血样，检测血浆白细胞介素-6、c反应蛋白和血脂。切除上颌骨和下颌骨进行骨质流失分析。结果：辛伐他汀治疗可减轻牙周炎引起的全身炎症和内皮功能障碍。此外，辛伐他汀改善血脂和减少牙槽骨丢失。结论：辛伐他汀治疗除了改善血脂外，还可能降低与牙周炎相关的心血管事件的其他预测因子。
Background and Objective: It has been demonstrated that periodontitis induces systemic inflammation, which may impair endothelial function leading to increased cardiovascular risk. The aim of this study was to evaluate the effect of simvastatin on systemic inflammatory markers and endothelial dysfunction induced by periodontitis.Material and Methods: Wistar rats were subjected to ligature-induced experimental periodontitis. Eight days after the procedure, the ligature and sham groups were randomly assigned to receive simvastatin or vehicle once a day until the 14th day, when the effects of acetylcholine and sodium nitroprusside on blood pressure were evaluated. Blood samples were collected and evaluated for plasma interleukin-6, C-reactive protein and lipids. The maxilla and mandible were removed for bone loss analysis.Results: Simvastatin treatment reduced systemic inflammation and endothelial dysfunction induced by periodontitis. Furthermore, simvastatin improved the blood lipid profile and reduced alveolar bone loss.Conclusion: Simvastatin treatment, in addition to the improvement on serum lipid profile, may reduce other predictors of cardiovascular events associated with periodontitis.