Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine
Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine
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DOI：
10.1128/aac.02889-14
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发表时间：
2014-08-01
影响因子：
4.9
通讯作者：
Drakeley, Chris
中科院分区：
文献类型：
--
作者：
Eziefula, Alice C.;Pett, Helmi;Drakeley, Chris
对经荧光斑点试验排除严重G6PD缺乏症的乌干达单纯性恶性疟疾患儿进行了葡萄糖-6-磷酸脱氢酶(G6PD)酶功能和基因分型检测。G6PD A杂合子和半合子/纯合子患者治疗后血红蛋白浓度呈剂量依赖性降低。未观察到严重贫血。
Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A - heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.