Selective cine-arylation of tert-cyclobutanols with indoles enabled by nickel catalysis
Selective cine-arylation of tert-cyclobutanols with indoles enabled by nickel catalysis
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镍催化下叔环丁醇与吲哚的选择性电影芳基化
DOI：
10.1039/d1cc01233a
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发表时间：
2021-04-06
影响因子：
4.9
通讯作者：
Zhou, Bingwei
中科院分区：
文献类型：
--
作者：
Hu, Yuanyuan;Luo, Honggen;Zhou, Bingwei
在以前的文献中，叔环丁醇被广泛研究用于C-C键的活化，仅导致普通伽马取代酮的形成。在这里，我们首次报道了镍催化的叔环丁醇与吲哚的电影芳基化反应，以获得在叔环丁醇的C3位具有不寻常的位置选择性的β-芳基酮。该反应具有富含稀土的镍催化剂、良好的区域选择性、原子经济性高、底物范围广等特点。
In previous literature, tert-cyclobutanols are widely studied for C-C bond activation exclusively leading to the formation of ordinary gamma-substituted ketones. Herein, we first report a nickel-catalyzed cine-arylation of tert-cyclobutanols with indoles to access beta-aryl ketones with an unusual site-selectivity at the C3-position of tert-cyclobutanols. The reaction features earth-abundant nickel catalysis, excellent regioselectivity, high atom-economy, and broad substrate scope.