HIV-TB co-infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection
HIV-TB co-infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection
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DOI：
10.1111/odi.12390
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发表时间：
2016-04-01
期刊：
影响因子：
3.8
通讯作者：
Vyakarnam, A.
中科院分区：
文献类型：
--
作者：
Ahmed, A.;Rakshit, S.;Vyakarnam, A.
HIV感染通过主要通过杀死和改变CD4 T细胞功能来损害宿主的免疫系统，使宿主易患结核病。HIV感染如何破坏CD4 T细胞功能，特别是损害宿主对结核分枝杆菌的免疫力，人们对此知之甚少，这是开发更好的疫苗或基于免疫的策略以控制和监测HIV感染受试者中结核病的关键障碍。这篇综述考虑了HIV感染受试者中改变的损害抗结核免疫的关键途径。
HIV infection predisposes the host to tuberculosis by impairing the hosts' immune system principally by killing and altering CD4 T-cell function. How HIV infection disrupts CD4 T-cell function, which specifically compromises host immunity to Mycobacterium tuberculosis, is poorly understood and is a critical roadblock in developing better vaccine- or immune-based strategies to control and monitor TB in HIV-infected subjects. This review considers key pathways that are altered in HIV-infected subjects that impair anti-TB immunity.