Approaches to cell delivery: substrates and scaffolds for cell therapy.
Approaches to cell delivery: substrates and scaffolds for cell therapy.
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DOI：
10.1159/000357369
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Joydip Kundu;A. Michaelson;Petr Baranov;M. Young;R. Carrier
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文献类型：
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作者：
Joydip Kundu;A. Michaelson;Petr Baranov;M. Young;R. Carrier
视网膜变性与光感受器的丧失有关，是永久性视力障碍的主要原因，影响着全世界数百万人。视网膜相关性黄斑变性和视网膜色素变性是两种常见的视网膜疾病，导致感光细胞丧失和视力受损或失明。目前，可用的治疗方法只能延缓视网膜变性的进展，并且没有治疗方法可以恢复永久性视力丧失。正在进行研究以开发通过将光感受器前体细胞和视网膜色素上皮递送到视网膜下腔来再生受损视网膜的方法。细胞移植的挑战包括植入后有限的存活和体内异常细胞结构的形成。视网膜组织工程通过将视网膜祖细胞以支架为基础输送到视网膜下腔，在治疗视网膜变性方面显示出巨大的前景和潜力。支架递送策略已显示在多种视网膜变性模型中增强细胞存活并指导细胞分化。在本章中，我们总结了不同的支架或基板为基础的移植技术，用于提供视网膜祖细胞/感光前体和视网膜色素上皮细胞的视网膜下腔的研究结果。
Retinal degeneration, associated with loss of photoreceptors, is the primary cause of permanent vision impairment, impacting millions of people worldwide. Age-related macular degeneration and retinitis pigmentosa are two common retinal diseases resulting in photoreceptor loss and vision impairment or blindness. Presently, available treatments can only delay the progress of retinal degeneration, and there are no treatments that can restore permanent vision loss. Research is underway to develop methods of regenerating the impaired retina by delivering photoreceptor precursor cells and retinal pigment epithelium to the subretinal space. Challenges to cell transplantation include limited survival upon implantation and the formation of abnormal cell architectures in vivo. Retinal tissue engineering shows immense promise and potential in treatment of retinal degeneration by employing scaffold-based delivery systems of retinal progenitor cells to the subretinal space. Scaffold delivery strategy has been shown to enhance the cell survival and direct cell differentiation in a variety of retinal degenerative models. In this chapter, we summarize the research findings on different scaffold- or substrate-based transplantation techniques used to deliver retinal progenitor/photoreceptor precursors and retinal pigment epithelial cells to the subretinal space.