Regulation of autophagy fires up the cold tumor microenvironment to improve cancer immunotherapy.
Regulation of autophagy fires up the cold tumor microenvironment to improve cancer immunotherapy.
复制标题
自噬调节激活冷肿瘤微环境以改善癌症免疫治疗
DOI：
10.3389/fimmu.2022.1018903
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
Zhou, Suna
中科院分区：
文献类型：
--
作者：
Jin, Zhicheng;Sun, Xuefeng;Wang, Yaoyao;Zhou, Chao;Yang, Haihua;Zhou, Suna
关键词：
免疫治疗，如免疫检查点抑制剂（ICI）和嵌合抗原受体（CAR）T细胞，已经彻底改变了对传统疗法具有抗性的晚期和转移性肿瘤患者的治疗。然而，免疫抑制的肿瘤微环境（TME）导致对免疫疗法的弱反应。因此，为了充分发挥免疫治疗和障碍屏障的潜力，必须探索如何将冷TME转化为热TME。自噬是一个重要的细胞过程，它在TME的细胞组分中保持细胞稳定性，有助于表征免疫抑制性TME。靶向自噬通过影响抗原释放、抗原呈递、抗原识别和免疫细胞运输来点燃免疫抑制性TME，从而增强癌症免疫疗法的有效性并克服对免疫疗法的抗性。本文综述了TME的特点和组成，探讨了自噬在TME的表征和调控中的机制和作用，并讨论了基于自噬的免疫治疗辅助增强剂，以提高免疫治疗的有效性。
Immunotherapies, such as immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T cells, have revolutionized the treatment of patients with advanced and metastatic tumors resistant to traditional therapies. However, the immunosuppressed tumor microenvironment (TME) results in a weak response to immunotherapy. Therefore, to realize the full potential of immunotherapy and obstacle barriers, it is essential to explore how to convert cold TME to hot TME. Autophagy is a crucial cellular process that preserves cellular stability in the cellular components of the TME, contributing to the characterization of the immunosuppressive TME. Targeted autophagy ignites immunosuppressive TME by influencing antigen release, antigen presentation, antigen recognition, and immune cell trafficking, thereby enhancing the effectiveness of cancer immunotherapy and overcoming resistance to immunotherapy. In this review, we summarize the characteristics and components of TME, explore the mechanisms and functions of autophagy in the characterization and regulation of TME, and discuss autophagy-based therapies as adjuvant enhancers of immunotherapy to improve the effectiveness of immunotherapy.
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影响因子：
13.3
作者：
Brun, Sonia;Bestion, Eloine;Raymond, Eric;Bassissi, Firas;Jilkova, Zuzana Macek;Mezouar, Soraya;Rachid, Madani;Novello, Marie;Tracz, Jennifer;Hamai, Ahmed;Lalmanach, Gilles;Vanderlynden, Lise;Legouffe, Raphael;Stauber, Jonathan;Schubert, Thomas;Plach, Maximilian G.;Courcambeck, Jerome;Drouot, Cyrille;Jacquemot, Guillaume;Serdjebi, Cindy;Roth, Gael;Baudoin, Jean-Pierre;Ansaldi, Christelle;Decaens, Thomas;Halfon, Philippe
通讯作者：
Halfon, Philippe
影响因子：
15.9
作者：
Alissafi, Themis;Hatzioannou, Aikaterini;Verginis, Panayotis
通讯作者：
Verginis, Panayotis
影响因子：
5.5
作者：
Davuluri GVN;Chen CC;Chiu YC;Tsai HW;Chiu HC;Chen YL;Tsai PJ;Kuo WT;Tsao N;Lin YS;Chang CP
通讯作者：
Chang CP
DOI：
10.33696/cancerimmunol.3.041
发表时间：
2021
期刊：
Journal of cancer immunology
影响因子：
--
作者：
Gupta G;Borglum K;Chen H
通讯作者：
Chen H
影响因子：
11.8
作者：
Becher, Juliane;Simula, Luca;Cecconi, Francesco
通讯作者：
Cecconi, Francesco