Increased IgG 3:4 ratios in adolescent antisocial females: evidence of Th1/Th2 imbalance?
Increased IgG 3:4 ratios in adolescent antisocial females: evidence of Th1/Th2 imbalance?
复制标题
青少年反社会女性中 IgG 3:4 比例增加：Th1/Th2 失衡的证据？
DOI：
10.1016/s0889-1591(02)00027-2
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Gardner,William
中科院分区：
文献类型：
--
作者：
Pajer,Kathleen;Rabin,Bruce;Gardner,William
Female antisocial behavior in adolescence and late childhood has been associated with low basal cortisol levels. Because low cortisol has also been correlated with T helper cell Type 1 (Th1) predominance and suppression of T helper cell Type 2 (Th2), we investigated whether adolescent antisocial girls demonstrated this immunologic profile. Using plasma levels of IgG3 and IgG4 as markers for Th1 and Th2 activity, we studied IgG 3:4 ratios in 16-year-old girls with conduct disorder (CD) (n=42) or no psychiatric disorder (normal controls (NC)) (n=35). The mean IgG 3:4 ratio was higher in the CD group; this relationship remained significant after controlling for the effects of other variables. These data indicate that immunologic abnormalities are present in adolescent antisocial girls. Future studies should measure cytokine levels and investigate the clinical implications of these findings.
