Prostate cancer risk and serum levels of insulin and leptin: a population-based study
Prostate cancer risk and serum levels of insulin and leptin: a population-based study
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DOI：
10.1093/jnci/93.10.783
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发表时间：
2001-05-16
影响因子：
10.3
通讯作者：
Stanczyk, FZ
中科院分区：
文献类型：
--
作者：
Hsing, AW;Chua, S;Stanczyk, FZ
背景：在以前的一项针对中国男性的研究中，我们发现腰臀比（WHR）较高的男性患前列腺癌的风险较高。由于瘦素和胰岛素与身体脂肪分布有关，我们研究了瘦素和胰岛素是否与前列腺癌风险相关。研究方法：从中国上海随机抽取128例前列腺癌患者和306例健康对照者的血液样本。流行病学信息和人体测量数据收集个人访谈。血清瘦素，胰岛素和性激素水平测定采用放射免疫法，胰岛素样生长因子-I（IGF-I）测定采用酶联免疫吸附试验。多元逻辑回归分析用于估计前列腺癌与血清胰岛素和瘦素水平相关的比值比。结果：在校正体重指数、腰臀比、IGF-I和性激素水平后，较高的血清胰岛素水平与前列腺癌风险显著升高相关（P <0.001）。胰岛素水平最高三分位数的男性患前列腺癌的风险是最低三分位数男性的2.56倍（95%置信区间[CI] = 1.38 - 4.75）。无论WHR的三分位数水平如何，较高的血清胰岛素水平与前列腺癌风险增加相关：WHR（>0.900）和胰岛素（>8.83 rhoU/mL）最高三分位数的男性患前列腺癌的风险是两者最低三分位数的男性的8.55倍（95% CI = 2.80至26.10），WHR（> 0.900）和胰岛素（> 8.83 rhoU/mL）最低三分位数的男性患前列腺癌的风险是WHR（> 0.900）和胰岛素（> 8.83 rhoU/mL）最低三分位数的男性的8.55倍（95% CI = 2.80至26.10）。
Background: In a previous study of Chinese men, we found that men with a higher waist-to-hip ratio (WHR) have a higher prostate cancer risk. Because leptin and insulin are related to body fat distribution, we examined whether leptin and insulin were associated with prostate cancer risk. Methods: Blood samples were collected from 128 case patients with incident prostate cancer and from 306 healthy control subjects randomly selected from residents of Shanghai, China. Epidemiologic information and anthropometric measurements were collected in personal interviews. Serum leptin, insulin, and sex hormone levels were measured by radioimmunoassay, and insulin-like growth factor-I (IGF-I) was measured by enzyme-linked immunosorbent assay. Multiple logistic regression analyses were used to estimate odds ratios for prostate cancer in relation to serum insulin and leptin levels. All statistical tests were two-sided, Results: After adjustment for body mass index, WHR, IGF-I, and sex hormone levels, higher serum insulin levels were associated with a statistically significantly elevated risk of prostate cancer (P < .001). Men in the highest tertile of insulin levels had a 2.56-fold (95% confidence interval [CI] = 1.38 to 4.75) risk of prostate cancer compared with men in the lowest tertile. Regardless of the tertile level of WHR, higher serum insulin levels were associated with an increased risk of prostate cancer: Men in the highest tertiles of WHR (>0.900) and insulin (>8.83 rhoU/mL) had 8.55 times (95% CI = 2.80 to 26.10) the prostate cancer risk of men in the lowest tertiles of both, and those in the lowest tertile of WHR (