Evidence of Hormonal Basis for Improved Survival Among Females With Trauma-Associated Shock: An Analysis of the National Trauma Data Bank
Evidence of Hormonal Basis for Improved Survival Among Females With Trauma-Associated Shock: An Analysis of the National Trauma Data Bank
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DOI：
10.1097/ta.0b013e3181efc67b
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发表时间：
2010-09-01
影响因子：
--
通讯作者：
Cornwell, Edward E.
中科院分区：
文献类型：
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作者：
Haider, Adil H.;Crompton, Joseph G.;Cornwell, Edward E.
背景：基础科学研究表明，性激素会影响创伤性休克后的生存。本研究旨在确定性别对不同激素相关年龄组的创伤患者死亡率的独立影响。方法：回顾国家创伤数据库中包含的休克严重创伤患者。根据可能的激素状态将患者分为三组：激素前组（年龄，0-12 岁）、激素组（年龄，13-64 岁）和激素后组（年龄，>= 65 岁）。使用多元逻辑回归分析性别对每组死亡率的独立影响，并调整解剖学和生理学损伤严重程度。结果：共有 48,394 名患者符合我们的纳入标准（损伤严重程度评分 >= 16 且收缩压 = 65 岁），其中性激素的影响不存在或减弱。这些发现表明，激素差异在创伤性休克后基于性别的结果差异中发挥了作用。
Background: Basic science research suggests that sex hormones affect survival after traumatic shock. This study sought to determine the independent effect of gender on mortality among trauma patients in different hormone-related age groups.Methods: Review of severely injured trauma patients with shock included in the National Trauma Databank. Patients were stratified into three groups on the basis of likely hormonal status: prehormonal (age, 0-12 years), hormonal (age, 13-64 years), and posthormonal (age, >= 65 years). Multiple logistic regression was used to analyze the independent effect of gender on mortality in each group, adjusting for anatomic and physiologic injury severity.Results: A total of 48,394 patients met our inclusion criteria (Injury Severity Score >= 16 and systolic blood pressure = 65 years) where the effects of sex hormones are absent or diminished. These findings suggest that hormonal differences play a role in the gender-based outcome disparities after traumatic shock.