Polymeric micelles with ionic cores containing biodegradable cross-links for delivery of chemotherapeutic agents.
Polymeric micelles with ionic cores containing biodegradable cross-links for delivery of chemotherapeutic agents.
复制标题
DOI：
10.1021/bm9013364
复制
发表时间：
2010-04-12
影响因子：
6.2
通讯作者：
Bronich, Tatiana K.
中科院分区：
文献类型：
--
作者：
Kim, Jong Oh;Sahay, Gaurav;Kabanov, Alexander V.;Bronich, Tatiana K.
开发了具有含生物可降解交联的离子核的新型功能性聚合物纳米载体用于递送化疗剂。以聚环氧乙烷-b-聚甲基丙烯酸（PEO-b-PMA）嵌段离聚体复合物（BIC）和二价金属离子（Ca ~（2+））为模板剂。通过使用胱胺作为可生物降解的交联剂将二硫键引入到离子核中。得到的交联胶束与二硫键代表软，水凝胶样纳米球，并表现出时间依赖性降解的条件下模仿细胞内还原环境。核心的离子特征使得交联胶束中的阿霉素（DOX）负载量（50%w/w）达到非常高的水平。与不含二硫键的胶束制剂相比，DOX负载的可降解交联胶束对人A2780卵巢癌细胞表现出更强的细胞毒性。这些新型的可生物降解的交联胶束有望成为抗癌药物递送的有吸引力的候选者。
Novel functional polymeric nanocarriers with ionic cores containing biodegradable cross-links were developed for delivery of chemotherapeutic agents. Block ionomer complexes (BIC) of poly(ethylene oxide)-b-poly(methacylic acid) (PEO-b-PMA) and divalent metal cations (Ca2+) were utilized as templates. Disulfide bonds were introduced into the ionic cores by using cystamine as a biodegradable cross-linker. The resulting cross-linked micelles with disulfide bonds represented soft, hydrogel-like nanospheres and demonstrated a time-dependent degradation in the conditions mimicking the intracellular reducing environment. The ionic character of the cores allowed to achieve a very high level of doxorubicin (DOX) loading (50% w/w) into the cross-linked micelles. DOX-loaded degradable cross-linked micelles exhibited more potent cytotoxicity against human A2780 ovarian carcinoma cells as compared to micellar formulations without disulfide linkages. These novel biodegradable cross-linked micelles are expected to be attractive candidates for delivery of anticancer drugs.
登录
查看更多内容
影响因子：
4.7
作者：
Lu, ZR;Wang, XH;Buswell, HR
通讯作者：
Buswell, HR
影响因子：
4.7
作者：
Sahay, Gaurav;Batrakova, Elena V.;Kabanov, Alexander V.
通讯作者：
Kabanov, Alexander V.
影响因子：
14
作者：
Sahay G;Kim JO;Kabanov AV;Bronich TK
通讯作者：
Bronich TK
影响因子：
10.8
作者：
Kim, Jong Oh;Kabanov, Alexander V.;Bronich, Tatiana K.
通讯作者：
Bronich, Tatiana K.
影响因子：
10.8
作者：
Neu, Michael;Germershaus, Oliver;Kissel, Thomas
通讯作者：
Kissel, Thomas