The occurrence of depressive symptoms in the preclinical phase of AD -: A population-based study
The occurrence of depressive symptoms in the preclinical phase of AD -: A population-based study
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DOI：
10.1212/wnl.53.9.1998
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发表时间：
1999-12-10
期刊：
影响因子：
9.9
通讯作者：
Bäckman, L
中科院分区：
文献类型：
--
作者：
Berger, AK;Fratiglioni, L;Bäckman, L
目的：研究AD诊断前3年的临床前抑郁症状。研究方法：作者比较了AD患者和非痴呆个体的基线情绪和动机相关的抑郁症状，并评估了临床前AD的抑郁症状是否与自我感知的记忆问题有关。参与者来自瑞典斯德哥尔摩一项基于人群的老龄化和痴呆症纵向研究。样本包括222名74岁以上的人，他们被随访了3年。34人在随访时发展为AD，而188人仍然没有痴呆。根据精神障碍诊断和统计手册第3版修订版的标准进行痴呆诊断。采用综合精神病理评定量表评定抑郁症状。结果：在基线时，AD患者比非痴呆患者有更多的抑郁症状。抑郁症的动机相关症状占主导地位（例如，缺乏兴趣、能量损失、注意力难以集中）。当调整主观记忆投诉时，这种关联仍然存在。结论：AD患者的抑郁症状在临床前升高，这种升高不仅仅是自我认知困难的副产品。因此，抑郁症状可能是AD临床前阶段的一部分。
Objective: To examine preclinical depressive symptoms 3 years before the diagnosis of AD. Methods: The authors compared incident AD patients and nondemented individuals in terms of baseline mood- and motivation-related symptoms of depression, and assessed whether depressive symptoms in preclinical AD are related to self-perceived memory problems. Participants came from a population-based longitudinal study on aging and dementia in Stockholm, Sweden. The sample consisted of 222 persons older than 74 years who were followed for a 3-year interval. Thirty-four individuals had developed AD at follow-up, whereas 188 remained nondemented. Dementia diagnosis was made according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised. Depressive symptoms were assessed by the Comprehensive Psychopathological Rating Scale. Results: The incident AD patients had more depressive symptoms than the nondemented persons at baseline. There was a dominance of motivation-related symptoms of depression (e.g., lack of interest, loss of energy, concentration difficulties) in preclinical AD. This association remained when adjusting for subjective memory complaints. Conclusions: Depressive symptoms are elevated preclinically in AD, and this elevation is not merely a by-product of self-perceived cognitive difficulties. Thus, depressive symptoms may be part of the preclinical phase in AD.