Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota.
Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota.
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DOI：
10.1038/s41598-020-77313-6
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发表时间：
2020-11-23
影响因子：
4.6
通讯作者：
Migura-Garcia L
中科院分区：
文献类型：
--
作者：
Correa-Fiz F;Neila-Ibáñez C;López-Soria S;Napp S;Martinez B;Sobrevia L;Tibble S;Aragon V;Migura-Garcia L
药物饲料是控制养猪生产中猪链球菌病发生的常见策略，但饲料添加剂可能是过敏疗法的替代方案。在一个患有断奶后猪链球菌病的农场中，测试了以下添加剂：溶菌酶（Lys）、中链脂肪酸加溶菌酶（FA + Lys）、FA加天然抗炎剂（FA + antiinf）和阿莫西林（Amox）。在研究过程中，FA + antiinf 和 Amox 组表现出与猪链球菌病相符的临床症状的患病率低于其他组。 FA + antiinf 组的仔猪鼻腔和粪便微生物群表现出高度多样性和丰富性。膳食补充剂对粪便微生物群没有重大影响，其中 Mitsuokella 属是 FA + Lys 组中唯一存在差异的微生物。在鼻腔微生物群中，来自 FA + antiinf 的仔猪表现出来自瘤胃球菌科的序列变体的较高差异丰度，以及来自周球菌科的未分类属的丰度较低。一般来说，我们检测到鼻腔微生物群的变化比粪便微生物群的变化更显着，并发现母猪的胎次影响其后代的微生物群组成，后备母猪所生的仔猪表现出较低的丰富度和多样性。我们的结果表明，在农场去除抗菌剂时，添加剂可能有助于控制断奶后疾病。
Medicated feed is a common strategy to control the occurrence of Streptococcus suis disease in swine production, but feed additives may constitute an alternative to metaphylaxis. In a farm with post-weaning S. suis disease, the following additives were tested: lysozyme (Lys), medium chain fatty acids plus lysozyme (FA + Lys), FA plus a natural anti-inflammatory (FA + antiinf) and amoxicillin (Amox). During the course of the study, FA + antiinf and Amox groups showed lower prevalence of clinical signs compatible with S. suis disease than the rest of the groups. Piglets from the FA + antiinf group showed high diversity and richness in their nasal and faecal microbiota. Diet supplements did not have major effects on the faecal microbiota, where the genus Mitsuokella was the only differentially present in the FA + Lys group. In the nasal microbiota, piglets from FA + antiinf presented higher differential abundance of a sequence variant from Ruminococcaceae and lower abundance of an unclassified genus from Weeksellaceae. In general, we detected more significant changes in the nasal than in the feacal microbiota, and found that parity of the dams affected the microbiota composition of their offspring, with piglets born to gilts exhibiting lower richness and diversity. Our results suggest that additives could be useful to control post-weaning disease when removing antimicrobials in farms.