A design logic for sequential segmentation across organisms.
A design logic for sequential segmentation across organisms.
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跨生物体顺序分割的设计逻辑。
DOI：
10.1111/febs.16899
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Özbudak,ErtuğrulM
中科院分区：
文献类型：
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作者：
Simsek,MFethullah;Özbudak,ErtuğrulM
许多生物体表现出其身体结构的同色异质区划。这些区室的分割在不同的门中依次发生。在几个连续分段的物种中，发现了周期性活跃的分子钟和信号梯度。提出时钟来控制分段的时序，而提出梯度来指示分段边界的位置。然而，时钟和梯度分子的身份因物种而异。此外，当小尾芽细胞群无法建立长程信号梯度时，基底脊索动物文昌鱼的顺序分割在后期继续进行。因此，仍有待解释如何通过使用不同的分子或具有不同空间轮廓的分子来实现保守的形态特征（即顺序分割）。在这里，我们首先关注脊椎动物胚胎体节的顺序分割，然后与其他物种进行比较。此后，我们提出了一个候选设计原则，有可能回答这个令人费解的问题。
Multitudes of organisms display metameric compartmentalization of their body plan. Segmentation of these compartments happens sequentially in diverse phyla. In several sequentially segmenting species, periodically active molecular clocks and signaling gradients have been found. The clocks are proposed to control the timing of segmentation, while the gradients are proposed to instruct the positions of segment boundaries. However, the identity of the clock and gradient molecules differs across species. Furthermore, sequential segmentation of a basal chordate,Amphioxus, continues at late stages when the small tail bud cell population cannot establish long‐range signaling gradients. Thus, it remains to be explained how a conserved morphological trait (i.e., sequential segmentation) is achieved by using different molecules or molecules with different spatial profiles. Here, we first focus on sequential segmentation of somites in vertebrate embryos and then draw parallels with other species. Thereafter, we propose a candidate design principle that has the potential to answer this puzzling question.