Anti-inflammatory effects of hydroxycinnamic acid derivatives
Anti-inflammatory effects of hydroxycinnamic acid derivatives
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DOI：
10.1016/j.bbrc.2007.04.178
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发表时间：
2007-06-29
影响因子：
3.1
通讯作者：
Ushio, Hideki
中科院分区：
文献类型：
--
作者：
Nagasaka, Reiko;Chotimarkorn, Chatchawan;Ushio, Hideki
NF-κ B家族转录因子参与多种细胞过程，包括分化、增殖和炎症。据报道，羟基肉桂酸衍生物（HAD）是NF-κ B活化的抑制剂。米糠油中含有大量的植物甾醇阿魏酸酯，是HAD的一种。我们研究了阿魏酸植物甾醇酯对巨噬细胞NF-κ B活化的影响。阿魏酸环木菠萝烯酯（CAF）能显著降低脂多糖（LPS）诱导的NO生成，抑制诱导型NO合成酶和环氧合酶-2的mRNA表达，上调SOD活性。电泳迁移率变动分析显示CAF抑制NF-κ B的DNA结合。CAF和植物甾醇阿魏酸酯可能具有潜在的抗炎特性。(C)2007爱思唯尔公司All rights reserved.
NF-kappa B family of transcription factors are involved in numerous cellular processes, including differentiation, proliferation, and inflammation. It was reported that hydroxycinnamic acid derivatives (HADs) are inhibitors of NF-kappa B activation. Rice bran oil contains a lot of phytosteryl ferulates, one of HADs. We have investigated effects of phytosteryl ferulates on NF-kappa B activation in macrophage. Cycloartenyl ferulate (CAF), one of phytosteryl ferulates, significantly reduced lipopolysaccharide (LPS)-induced NO production and mRNA expression of inducible NO synthase and cyclooxygenese-2 but upregulated SOD activity. Electrophoresis mobility shift assay revealed that CAF inhibited DNA-binding of NF-kappa B. CAF and phytosteryl ferulates probably have potentially anti -inflammatory properties. (C) 2007 Elsevier Inc. All rights reserved.