Neural mechanisms of antinociceptive effects of hypnosis
Neural mechanisms of antinociceptive effects of hypnosis
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DOI：
10.1097/00000542-200005000-00013
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发表时间：
2000-05-01
期刊：
影响因子：
8.8
通讯作者：
Maquet, P
中科院分区：
文献类型：
--
作者：
Faymonville, ME;Laureys, S;Maquet, P
背景催眠对痛觉调制的神经机制尚不清楚。在这项研究中，我们用正电子发射断层扫描在11名健康志愿者，以确定在催眠调节大脑反应的伤害性stimulation.Methods：该协议使用了析因设计与两个因素：状态（催眠状态，休息状态，心理意象）和刺激（温暖的非伤害性与热伤害性刺激施加到右鱼际隆起）。在每种情况下，用O-15-水技术获得两次脑血流扫描。每次扫描后，要求受试者对疼痛感觉和不愉快进行评级。使用统计参数映射来确定伤害性刺激和催眠状态的主要影响以及刺激与状态的相互作用（即，结果：催眠降低了伤害性刺激引起的疼痛感和不愉快感。伤害性刺激引起丘脑核团、前扣带回和岛叶皮质的局部脑血流量增加。催眠状态诱导了右侧纹外区和前扣带皮层的显著激活。交互作用分析表明，前（中）扣带皮层的活动与疼痛知觉和不愉快的不同，在催眠状态比在控制situation.Conclusions：在催眠状态下的伤害性刺激的强度和不愉快的减少。此外，催眠对疼痛的调节是由前扣带皮层介导的。
Background The neural mechanisms underlying the modulation of pain perception by hypnosis remain obscure. In this study, we used positron emission tomography in 11 healthy volunteers to identify the brain areas in which hypnosis modulates cerebral responses to a noxious stimulus.Methods: The protocol used a factorial design with two factors: state (hypnotic state, resting state, mental imagery) and stimulation (warm non-noxious vs. hot noxious stimuli applied to right thenar eminence). Two cerebral blood flow scans were obtained with the O-15-water technique during each condition. After each scan, the subject was asked to rate pain sensation and unpleasantness, Statistical parametric mapping was used to determine the main effects of noxious stimulation and hypnotic state as well as state-by-stimulation interactions (i.e., brain areas that would be more or less activated in hypnosis than in control conditions, under noxious stimulation).Results: Hypnosis decreased both pain sensation and the unpleasantness of noxious stimuli. Noxious stimulation caused an increase in regional cerebral blood flow in the thalamic nuclei and anterior cingulate and insular cortices. The hypnotic state induced a significant activation of a right-sided extrastriate area and the anterior cingulate cortex. The interaction analysis showed that the activity in the anterior (mid-)cingulate cortex was related to pain perception and unpleasantness differently in the hypnotic state than in control situations.Conclusions: Both intensity and unpleasantness of the noxious stimuli are reduced during the hypnotic state. in addition, hypnotic modulation of pain is mediated by the anterior cingulate cortex.