Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology.
Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology.
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DOI：
10.7150/ntno.62970
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Andreou C
中科院分区：
文献类型：
--
作者：
Kenry;Nicolson F;Clark L;Panikkanvalappil SR;Andreiuk B;Andreou C
近二十年来，表面增强拉曼散射（Sers）纳米粒子在肿瘤临床前成像中的应用越来越受到人们的关注。使用Sers纳米颗粒的拉曼成像提供了无与伦比的灵敏度，为分子靶向提供了平台，并赋予了多路复用和多模式成像能力。最近的进展不仅促进了Sers造影剂本身的优化，而且还通过拉曼成像方法和仪器的发展。在这篇文章中，我们回顾了拉曼散射和Sers的原理，目前的进展拉曼仪器特定于癌症成像，并讨论了生物手段，以确保选择性的Sers造影剂在体内摄取有针对性的，多路复用，和多模式成像应用。我们提供了我们的观点，必须解决的领域，以促进临床翻译的Sers造影剂在肿瘤学体内成像。
In the last two decades, the application of surface enhanced Raman scattering (SERS) nanoparticles for preclinical cancer imaging has attracted increasing attention. Raman imaging with SERS nanoparticles offers unparalleled sensitivity, providing a platform for molecular targeting, and granting multiplexed and multimodal imaging capabilities. Recent progress has been facilitated not only by the optimization of the SERS contrast agents themselves, but also by the developments in Raman imaging approaches and instrumentation. In this article, we review the principles of Raman scattering and SERS, present advances in Raman instrumentation specific to cancer imaging, and discuss the biological means of ensuring selective in vivo uptake of SERS contrast agents for targeted, multiplexed, and multimodal imaging applications. We offer our perspective on areas that must be addressed in order to facilitate the clinical translation of SERS contrast agents for in vivo imaging in oncology.