CRNDE: A Long Non-Coding RNA Involved in CanceR, Neurobiology, and DEvelopment.
CRNDE: A Long Non-Coding RNA Involved in CanceR, Neurobiology, and DEvelopment.
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DOI：
10.3389/fgene.2012.00270
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发表时间：
2012
影响因子：
3.7
通讯作者：
Graham LD
中科院分区：
文献类型：
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作者：
Ellis BC;Molloy PL;Graham LD
CRNDE是结直肠癌差异表达（non-protein-coding）的基因符号，是一种长链非编码RNA （lncRNA）基因，表达多种剪接变体，并表现出非常组织特异性的表达模式。CRNDE最初被确定为在结直肠癌中表达高度升高的lncRNA，但在许多其他实体肿瘤和白血病中也表达上调。事实上，在胶质瘤中，CRNDE是表达上调最多的lncRNA，在胶质瘤中，与其他癌症一样，它与“干性”特征有关。CRNDE在人类和小鼠大脑的特定区域表达；小鼠同源物在诱导多能干细胞中含量高，并在神经元分化过程中进一步增加。我们认为CRNDE是一种多功能lncRNA，其不同的剪接形式为调控复合物提供了特定的功能支架，如多梳抑制复合物2 （PRC2）和CoREST染色质修饰复合物，CRNDE有助于先导靶基因。
CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed (non-protein-coding), a long non-coding RNA (lncRNA) gene that expresses multiple splice variants and displays a very tissue-specific pattern of expression. CRNDE was initially identified as a lncRNA whose expression is highly elevated in colorectal cancer, but it is also upregulated in many other solid tumors and in leukemias. Indeed, CRNDE is the most upregulated lncRNA in gliomas and here, as in other cancers, it is associated with a “stemness” signature. CRNDE is expressed in specific regions within the human and mouse brain; the mouse ortholog is high in induced pluripotent stem cells and increases further during neuronal differentiation. We suggest that CRNDE is a multifunctional lncRNA whose different splice forms provide specific functional scaffolds for regulatory complexes, such as the polycomb repressive complex 2 (PRC2) and CoREST chromatin-modifying complexes, which CRNDE helps pilot to target genes.