THE EFFECT OF DRUGS ON SERUM HISTIDINE LEVELS IN RHEUMATOID-ARTHRITIS
THE EFFECT OF DRUGS ON SERUM HISTIDINE LEVELS IN RHEUMATOID-ARTHRITIS
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DOI：
10.1007/bf00541592
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发表时间：
1983-01-01
影响因子：
4
通讯作者：
BIRD, HA
中科院分区：
文献类型：
--
作者：
DIXON, JS;SITTON, NG;BIRD, HA
15例活动性类风湿性关节炎患者接受硫酸锌、三羟甲基氨基甲烷、巯甲丙脯酸、二次剂量的氯氮平或d-青霉胺和羟氯喹联合治疗24周。沿着监测血清组氨酸水平和疾病活动度，包括C反应蛋白、血浆粘度、关节指数、握力和晨僵。硫酸锌和三烯被发现是无效的，而其他药物都显示出二线行动的证据。在成功治疗期间发现血清组氨酸改善。低血清组氨酸的可能原因及其对治疗的反应进行了讨论。
Groups of 15 patients with active rheumatoid arthritis were treated for 24 weeks with zinc sulphate, trien, captopril, clozic in two doses or a combination ofd-penicillamine and hydroxychloroquine. Serum histidine levels were monitored along with measures of disease activity including C-reactive protein, plasma viscosity, articular index, grip strength and early morning stiffness. Zinc sulphate and trien were found to be ineffective while the other drugs all showed evidence of second-line action. Serum histidine was found to improve during successful therapy. The possible cause of low serum histidine and its response to therapy is discussed.