The cognitive enhancer T-588 partially compensates the motor and associative learning impairments induced by scopolamine injection in mice
The cognitive enhancer T-588 partially compensates the motor and associative learning impairments induced by scopolamine injection in mice
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DOI：
10.1037/0735-7044.121.6.1203
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发表时间：
2007-12-01
影响因子：
1.9
通讯作者：
Delgado-Garcia, Jose M.
中科院分区：
文献类型：
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作者：
Eleore, Lyndell;Lopez-Ramos, Juan C.;Delgado-Garcia, Jose M.
作者研究了 T-588 对东莨菪碱诱导的成年小鼠获得经典眨眼条件反射记忆障碍的影响。与未治疗的小鼠相比，注射 0.3 mg/kg 东莨菪碱的小鼠在使用微量范式获得经典眨眼条件反射方面表现出明显的缺陷。 T-588（0.05% wt/vol，水溶液）与东莨菪碱（0.3 mg/kg）共同给药可显着防止联想学习中的这种缺陷。为了进一步评估 T-588 对运动协调和东莨菪碱引起的认知缺陷的影响，作者比较了成年对照或东莨菪碱治疗的小鼠在不同行为任务中的表现：旋转、物体识别、被动回避和前脉冲抑制。在所有这些任务中，作者发现，与对照组相比，注射东莨菪碱的小鼠的运动或认知能力显着受损。此外，T-588 与东莨菪碱共同给药可恢复单独使用东莨菪碱引起的缺陷。重要的是，与对照组获得的值相比，单独施用 T-588 不会引起任何变化。这些结果表明 T-588 可用作改善运动和联想学习障碍的药物。
The authors studied the effects of T-588 on scopolamine-induced memory impairments in the acquisition of a classical eyeblink conditioning in behaving adult mice. Mice injected with 0.3 mg/kg of scopolamine showed a marked deficit, compared with nontreated mice, in the acquisition of classical eyeblink conditioning using a trace paradigm. Coadministration of T-588 (0.05% wt/vol, in water) with scopolamine (0.3 mg/kg) significantly prevented this deficit in associative learning. To further assess the effects of T-588 on motor coordination and the cognitive deficits induced by scopolamine, the authors compared adult controls or scopolamine-treated mice in different behavioral tasks: rotarod, object recognition, passive avoidance, and prepulse inhibition. In all of these tasks, the authors found a significant impairment in the motor or cognitive abilities in scopolamine-injected mice, compared with controls. In addition, the coadministration of T-588 with scopolamine restored deficits induced by scopolamine alone. Importantly, the administration of T-588 alone did not evoke any change compared with values obtained for controls. These results suggest that T-588 could be used as a pharmacological agent to improve motor and associative learning disorders.