Deep-sea water improves cardiovascular hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) rabbits
Deep-sea water improves cardiovascular hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) rabbits
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DOI：
10.1248/bpb.31.38
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发表时间：
2008-01-01
影响因子：
2
通讯作者：
Hazama, Akihiro
中科院分区：
文献类型：
--
作者：
Katsuda, Shin-ichiro;Yasukawa, Takeshi;Hazama, Akihiro
深海水中含有丰富的矿物质，如镁、钙和钾，它们被认为与预防心血管疾病有关。我们研究了深海海水对黑泽明和草木高胆固醇血症(KHC)兔心血管血流动力学的影响。日本室户角附近的深海海水被抽出，矿物成分被提炼到1000度的硬度。24只4月龄KHC大耳白兔分别饮用精制深海水和自来水6个月。在戊巴比妥钠麻醉下记录升主动脉的压力、流量和波形。深海水组的动脉收缩压、舒张压、脉压、平均动脉压和总外周阻力均显著低于对照组。喂水后两组大鼠血脂水平、血浆肾素和无神经降压素转换酶活性及电解质水平变化差异均无统计学意义(P>0.05)。深海水组血清中镁离子水平的轻微升高可能不是抑制轻度高血压的原因。根据我们的结果，我们得出结论，深海水可以改善心血管血流动力学，尽管影响血压的因素尚不清楚。
Deep-sea water is rich in minerals, e.g., Mg, Ca, and K which have been considered to be associated with prevention of cardiovascular disease. We investigated the effect of deep-sea water on cardiovascular hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) rabbits. Deep-sea water was pumped in the offing of Cape Muroto in Japan and the mineral constituents were refined to a degree of hardness of 1000. Twenty four 4-month-old KHC rabbits were given refined deep-sea water (n= 12) and tap water (n=12) for 6 months. Pressure and flow, waves at the ascending aorta were recorded under pentobarbital anesthesia. Systolic, diastolic, pulse and mean arterial pressures and total peripheral resistance were significantly lower in the deep-sea water group than in the control group. There were no significant differences in changes in serum lipid levels, plasma renin and anuiotensin converting enzyme activities and electrolyte levels except for Mg2+ b after the feeding of the water between the two groups. A slight increase in serum Mg2+ level in the deep-sea water group may not account for the inhibition of mild hypertension. From our results, we conclude that deep-sea water could improve cardiovascular hemodynamics, even though the factors which affect the blood pressure are still unknown.