The phylogenic expression of plasmolipin in the vertebrate nervous system.
The phylogenic expression of plasmolipin in the vertebrate nervous system.
复制标题
脊椎动物神经系统中纤溶脂蛋白的系统发育表达。
DOI：
10.1007/bf00965699
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发表时间：
1991
影响因子：
4.4
通讯作者：
Flynn,CJ
中科院分区：
文献类型：
--
作者：
Sapirstein,VS;Nolan,CE;Fischer,I;Cochary,E;Blau,S;Flynn,CJ
纤溶脂蛋白是质膜蛋白脂质，是髓鞘质膜的主要成分（Cochary 等，1990）。在这项研究中，我们报告了脊椎动物神经系统中纤溶脂蛋白的系统发育表达。使用多克隆抗体进行蛋白质印迹分析，我们分析了软骨鱼、硬骨鱼、两栖动物、爬行动物、鸟类和哺乳动物的膜组分，包括髓磷脂。根据免疫检测，血浆脂蛋白似乎仅限于哺乳动物神经系统。哺乳动物中枢神经系统和周围神经系统的比较表明，这两个区域的血浆脂蛋白水平仅存在微小差异。在哺乳动物中，当比较大鼠、人类和牛的膜组分时，观察到很少的定量差异。纤溶脂蛋白的晚期进化表达导致其仅限于哺乳动物，这使得它在（主要）髓磷脂蛋白中独一无二。讨论了这些数据的潜在生理意义。
Plasmolipin is a plasma membrane proteolipid is a major myelin membrane component (Cochary et al., 1990). In this study we report the phylogenic expression of plasmolipin in the vertebrate nervous system. Using Western blot analysis with polyclonal antibodies, we have analyzed membrane fractions, including myelin, from elasmobranchs, teleosts, amphibians, reptiles, birds and mammals. On the basis of immune detection, plasmolipin appears to be restricted to the mammalian nervous system. Comparison of the central and peripheral nervous systems of mammals showed only minor differences in the level of plasmolipin in these two regions. Within mammals, little quantitative differences were observed when rat, human and bovine membrane fractions were compared. The late evolutionary expression of plasmolipin which results in its restriction to mammals makes it unique among the (major) myelin proteins. The potential physiologic significance of these data are discussed.