Manic episodes are associated with grey matter volume reduction - a voxel-based morphometry brain analysis
Manic episodes are associated with grey matter volume reduction - a voxel-based morphometry brain analysis
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DOI：
10.1111/j.1600-0447.2010.01586.x
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发表时间：
2010-12-01
影响因子：
6.7
通讯作者：
Landen, M.
中科院分区：
文献类型：
--
作者：
Ekman, C. J.;Lind, J.;Landen, M.
目的：为了研究无合并症的双相I型障碍患者的情感发作次数或病程是否与局部灰质体积变化相关，采用VBM分析了55例双相I型障碍患者的磁共振成像扫描。背外侧前额叶皮质额下回（DLPFC）灰质体积较小与一生中躁狂发作的次数显著相关。局部灰质体积和抑郁发作或疾病持续时间的终身数量之间没有关联被发现。结论：我们发现强有力的证据DLPFC体积的减少和躁狂发作的终身数量在双相I型障碍患者之间的线性相关性。有趣的是，已知DLPFC对执行功能很重要，因此本研究中的发现可能与双相情感障碍相关的执行认知缺陷有关。
Objective: To investigate whether the lifetime number of affective episodes or illness duration is associated with changes in local grey matter volume, in patients with bipolar I disorder without comorbid conditions.Method: Magnetic resonance imaging scans of 55 patients with bipolar I disorder were analysed using VBM.Results: Smaller grey matter volume in the inferior frontal gyri of the dorsolateral prefrontal cortices (DLPFC) correlated significantly to the lifetime number of manic episodes. No association between local grey matter volume and the lifetime number of depression episodes or illness duration was found.Conclusion: We found strong evidence for a linear correlation between a decrease in DLPFC volume and the lifetime number of manic episodes in patients with bipolar I disorder. Interestingly, DLPFC is known to be important for executive functions and the findings in this study might hence be linked to the executive cognitive deficits associated with bipolar disorder.