The regulation of RNA metabolism in hormone signaling and breast cancer.
The regulation of RNA metabolism in hormone signaling and breast cancer.
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激素信号中RNA代谢的调节与乳腺癌。
DOI：
10.1016/j.mce.2021.111221
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发表时间：
2021-06-01
影响因子：
4.1
通讯作者：
Yang D
中科院分区：
文献类型：
--
作者：
Wang X;Yang D
作为最常见的女性癌症，乳腺癌在全球女性癌症相关死亡人数中排名第二。大多数乳腺癌是激素受体阳性，通常用激素疗法治疗。因此，激素受体信号通路的表达水平在乳腺癌的发展和治疗中起着关键作用。激素受体信号通路的表达不仅在转录水平上受到调控，而且在转录后水平上受到蛋白质和rna的调控。除此之外，激素受体的功能也可以受到rna的调控。本文就rna在激素受体阳性乳腺癌中的作用作一综述。我们介绍了rna结合蛋白、mirna和lncrna如何调节激素受体信号通路中基因的mRNA稳定性和蛋白质功能。我们相信这些蛋白质和rna可以成为乳腺癌的潜在治疗靶点。
As the most frequent women’s cancer, breast cancer causes the second most cancer-related death in women worldwide. Majority of the breast cancers are hormone receptor-positive and commonly treated by hormone therapy. Thus, the expression levels of hormone receptors signaling pathways are pivotal in the development and therapy of breast cancer. The expression of hormone receptors signaling pathways is not only regulated at the transcription level but also at the post-transcription level by both proteins and RNAs. In addition to that, the function of hormone receptors can also be regulated by RNAs. In this review, we summarize the roles of RNAs in hormone receptor-positive breast cancer. We introduce how mRNA stability and protein function of genes in hormone receptors signaling pathways are regulated by RNA-binding proteins, miRNAs, and lncRNAs. We believe these proteins and RNAs can be potential therapeutic targets of breast cancer.