Suppressors of superoxide production from mitochondrial complex III.
Suppressors of superoxide production from mitochondrial complex III.
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DOI：
10.1038/nchembio.1910
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发表时间：
2015-11
影响因子：
14.8
通讯作者：
Brand MD
中科院分区：
文献类型：
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作者：
Orr AL;Vargas L;Turk CN;Baaten JE;Matzen JT;Dardov VJ;Attle SJ;Li J;Quackenbush DC;Goncalves RL;Perevoshchikova IV;Petrassi HM;Meeusen SL;Ainscow EK;Brand MD
Mitochondrial electron transport drives ATP synthesis but also generates reactive oxygen species (ROS), which are both cellular signals and damaging oxidants. Superoxide production by respiratory complex III is implicated in diverse signaling events and pathologies but its role remains controversial. Using high-throughput screening we identified compounds that selectively eliminate superoxide production by complex III without altering oxidative phosphorylation; they modulate retrograde signaling including cellular responses to hypoxic and oxidative stress.
