Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation
Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation
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DOI：
10.1016/j.freeradbiomed.2006.12.003
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发表时间：
2007-04-01
影响因子：
7.4
通讯作者：
Kanba, Shigenobu
中科院分区：
文献类型：
--
作者：
Hashioka, Sadayuki;Han, Youn-Hee;Kanba, Shigenobu
越来越多的证据表明，小胶质细胞活化是阿尔茨海默病（AD）的主要致病因素之一，因此抑制小胶质细胞的炎症活化似乎具有神经保护作用，并且是AD的潜在有用治疗。磷脂如磷脂酰丝氨酸（PS）和磷脂酰胆碱（PC）已被报道调节吞噬细胞的免疫功能。此外，已报道PS是一种益智药，可用作非处方记忆或认知增强剂。因此，我们评估了脂质体，其中包括PS和PC（PS/PC脂质体），对肿瘤坏死因子-α（TNF-α），一氧化氮（NO），和超氧化物（O-。(2)-)由淀粉样蛋白β（A β）和干扰素-γ（IFN-γ）诱导。用PS/PC脂质体预处理小胶质细胞显著抑制TNF-α、NO和O-。(2)-由A β/IFN-γ诱导的产生。这些结果表明，PS/PC脂质体通过抑制小胶质细胞活化具有神经保护和抗氧化特性，从而支持PS的益智和抗痴呆作用。(c)2007年爱思唯尔公司All rights reserved.
There is increasing evidence that microglial activation is one of the major pathogenic factors for Alzheimer's disease (AD) and the inhibition of the inflammatory activation of the microglia thus appears to be neuroprotective and a potentially useful treatment for AD. Phospholipids such as phosphatidlserine (PS) and phosphatidylcholine (PC) have been reported to modulate the immune function of phagocytes. In addition, PS has been reported to be a nootropics that can be used as nonprescription memory or cognitive enhancers. We therefore evaluated the effects of liposomes, which comprise both PS and PC (PS/PC liposomes), on the microglial production of tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), and superoxide (O-.(2)-) induced by amyloid beta (A beta) and interferon-gamma (IFN-gamma). Pretreatment of microglia with PS/PC liposomes considerably inhibited the TNF-alpha, NO and O-.(2)- production induced by A beta/IFN-gamma. These results suggest that PS/PC liposomes have both neuroprotective and antioxidative properties through the inhibition of microglial activation, thus supporting the nootropic and antidementia effect of PS. (c) 2007 Elsevier Inc. All rights reserved.